Anthracene-Bridged Photosensitizers for Effective and Safe Photodynamic Therapy,Chemistry of Materials

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Anthracene-Bridged Photosensitizers for Effective and Safe Photodynamic Therapy
Chemistry of Materials ( IF 7.2 ) Pub Date : 2023-01-19 , DOI: 10.1021/acs.chemmater.2c03274
Jucai Gao ₁ , Hui Yang ₁ , Yaru Lu ₂ , Qiankun Shi ₁ , Shidang Xu ₃ , Wenbo Wu ₂ , Fang Hu ₁ , Bin Liu ₃

Affiliation

Photodynamic therapy (PDT) is a minimally invasive therapeutic modality. However, the residual photosensitizers (PSs) after PDT can still produce toxic singlet oxygen (¹O₂) under sunlight to damage normal tissues. The PS that can be switched off after PDT is desirable but rare. Herein, we propose a general strategy to design effective and self-degradable PSs by embedding an anthracene bridge into donor–acceptor (D–A) structures. First, the steric anthracene can regulate the orbital distribution for enhancing the ¹O₂ production capacity. More importantly, the anthracene is responsive to the self-produced ¹O₂ for self-degradation. Besides, the degradation rate can be fine-tuned by the hydrophilicity of PSs. In this way, the PSs can realize a balance between treatment and suicide to ensure PDT and post-treatment safety. This work provides new insights into the design of degradable PSs with a clear mechanism, aiming to improve the post-safety of PDT.

中文翻译：

用于有效和安全光动力疗法的蒽桥接光敏剂

光动力疗法 (PDT) 是一种微创治疗方式。然而，PDT后残留的光敏剂(PSs)在阳光下仍会产生有毒的单线态氧( ¹ O ₂ )，对正常组织造成损伤。PDT 后可以关闭的 PS 是可取的，但很少见。在此，我们提出了一种通用策略，通过将蒽桥嵌入供体-受体 (D-A) 结构来设计有效且可自降解的 PS。首先，空间蒽可以调节轨道分布，提高¹ O _{2 的}生产能力。更重要的是，蒽对自产的¹ O ₂为了自我贬低。此外，降解速率可以通过 PS 的亲水性进行微调。通过这种方式，PSs 可以在治疗和自杀之间实现平衡，以确保 PDT 和治疗后的安全。这项工作为具有明确机制的可降解 PS 的设计提供了新的见解，旨在提高 PDT 的后安全性。

更新日期：2023-01-19

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