<br>降解的 TBBPA（二溴双酚 A）通过细胞凋亡和坏死途径具有高细胞毒性,Heliyon

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降解的 TBBPA（二溴双酚 A）通过细胞凋亡和坏死途径具有高细胞毒性
Heliyon ( IF 3.4 ) Pub Date : 2023-01-16 , DOI: 10.1016/j.heliyon.2023.e13003
Keitaro Suyama ₁ , Hitoshi Kesamaru ₂ , Takashi Okubo ₂ , Kazumi Kasatani ₂ , Keisuke Tomohara ₁ , Ayami Matsushima ₂ , Takeru Nose _{1,

2}

Affiliation

已经研究了包含双酚A(BPA)衍生物例如四溴双酚A(TBBPA)的卤化阻燃剂对人类健康的不利影响。然而，尽管这些卤化 BPA 很容易在环境中降解，但这些降解产物对生物体造成的风险却大多被忽视。为了评估降解的 TBBPA 和相关化合物的潜在毒性，我们检测了具有 1 至 4 个卤素原子的卤化双酚 A 衍生物的细胞毒性。结果表明，降解后的TBBPA衍生物对HeLa细胞表现出比TBBPA更强的细胞毒性。有趣的是，具有两个卤素原子的二卤化 BPA 衍生物在测试化合物中表现出最强的细胞毒性。此外，乳酸脱氢酶释放测定、荧光光谱和流式细胞术结果表明，二溴-BPA和二碘-BPA通过破坏HeLa细胞的细胞膜诱导细胞凋亡和坏死。此外，脱卤 TBBPA 和相关化合物的存在会抑制生长。这些结果表明，各种含阻燃剂产品中泄漏的卤化BPA衍生物需要严格监测，因为不仅TBBPA，而且其在环境中的降解产物也会对人体健康产生不利影响。

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High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

Halogenated flame retardants comprising bisphenol A (BPA) derivatives, such as tetrabromobisphenol A (TBBPA), have been studied their adverse effects on human health. However, despite the fact that these halogenated BPAs are easily degraded in the environment, the risks to living organisms due to these degraded products have mostly been overlooked. To evaluate the potential toxicity of degraded TBBPAs and related compounds, we examined the cytotoxicity of halogenated bisphenol A derivatives possessing one to four halogen atoms . The results indicated that the degraded TBBPA derivatives exhibited strong cytotoxicity against HeLa cells than TBBPA. Interestingly, the di-halogenated BPA derivatives possessing two halogen atoms exhibited the strongest cytotoxicity among tested compounds. In addition, a lactate dehydrogenase release assay, fluorescence spectroscopy and flow cytometry results indicated that dibromo-BPA and diiodo-BPA induced both apoptotic and necrotic cell death by damaging the cell membranes of HeLa cells. Moreover, growth was inhibited in the presence of dehalogenated TBBPA and related compounds. These findings suggest that halogenated BPA derivatives that leak from various flame-retardant-containing products require strict monitoring, as not only TBBPA but also its degraded products in environment can exert adverse effects to human health.

更新日期：2023-01-16

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