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Single Atom-Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo-Nanodynamic Therapy of Triple Negative Breast Cancer
Advanced Science ( IF 14.3 ) Pub Date : 2023-01-16 , DOI: 10.1002/advs.202206244 Qiqing Chen 1 , Min Zhang 1 , Hui Huang 2 , Caihong Dong 3 , Xinyue Dai 2 , Guiying Feng 1 , Ling Lin 1 , Dandan Sun 1 , Dayan Yang 1 , Lin Xie 1 , Yu Chen 2 , Jia Guo 4 , Xiangxiang Jing 1
Advanced Science ( IF 14.3 ) Pub Date : 2023-01-16 , DOI: 10.1002/advs.202206244 Qiqing Chen 1 , Min Zhang 1 , Hui Huang 2 , Caihong Dong 3 , Xinyue Dai 2 , Guiying Feng 1 , Ling Lin 1 , Dandan Sun 1 , Dayan Yang 1 , Lin Xie 1 , Yu Chen 2 , Jia Guo 4 , Xiangxiang Jing 1
Affiliation
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Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant breast cancers, especially triple-negative breast cancer (TNBC), have evolved to acquire specific antioxidant defense functions, significantly limiting the killing efficiency of SDT. Herein, the authors have engineered a distinct single copper atom-doped titanium dioxide (Cu/TiO2) nanosonosensitizer with highly catalytic and sonosensitive activities for synergistic chemodynamic and sonodynamic treatment of TNBC. The single-atom Cu is anchored on the most stable Ti vacancies of hollow TiO2 sonosensitizers, which not only substantially improved the catalytic activity of Cu-mediated Fenton-like reaction, but also considerably augmented the sonodynamic efficiency of TiO2 by facilitating the separation of electrons (e−) and holes (h+). Both the in vitro and in vivo studies demonstrate that the engineered single atom-doped nanosonosensitizers effectively achieved the significantly inhibitory effect of TNBC, providing a therapeutic paradigm for non-invasive and safe tumor elimination through the mutual process of sono/chemo-nanodynamic therapy based on multifunctional single-atom nanosonosensitizers.
中文翻译：
单原子掺杂纳米声敏剂用于三阴性乳腺癌相互优化的声/化学纳米动力疗法
声动力疗法（SDT）代表了一种有前途的乳腺癌治疗方式，它依赖于大量活性氧（ROS）的产生来诱导氧化应激损伤。然而，突变乳腺癌，尤其是三阴性乳腺癌（TNBC），已经进化获得特定的抗氧化防御功能，显着限制了SDT的杀伤效率。在此，作者设计了一种独特的单铜原子掺杂二氧化钛 (Cu/TiO 2 ) 纳米声敏剂，具有高度催化和声敏活性，可用于协同化学动力学和声动力学治疗 TNBC。单原子Cu锚定在空心TiO 2声敏剂最稳定的Ti空位上，这不仅大大提高了Cu介导的类Fenton反应的催化活性，而且通过促进分离，显着提高了TiO 2的声动力效率电子 (e − ) 和空穴 (h + )。体外和体内研究表明，工程化的单原子掺杂纳米声敏剂有效地实现了TNBC的显着抑制效果，通过基于声/化学纳米动力疗法的相互过程，为非侵入性和安全消除肿瘤提供了治疗范例。多功能单原子纳米声敏剂的研究。
更新日期：2023-01-16
中文翻译：
单原子掺杂纳米声敏剂用于三阴性乳腺癌相互优化的声/化学纳米动力疗法
声动力疗法（SDT）代表了一种有前途的乳腺癌治疗方式，它依赖于大量活性氧（ROS）的产生来诱导氧化应激损伤。然而，突变乳腺癌，尤其是三阴性乳腺癌（TNBC），已经进化获得特定的抗氧化防御功能，显着限制了SDT的杀伤效率。在此，作者设计了一种独特的单铜原子掺杂二氧化钛 (Cu/TiO 2 ) 纳米声敏剂，具有高度催化和声敏活性，可用于协同化学动力学和声动力学治疗 TNBC。单原子Cu锚定在空心TiO 2声敏剂最稳定的Ti空位上，这不仅大大提高了Cu介导的类Fenton反应的催化活性，而且通过促进分离，显着提高了TiO 2的声动力效率电子 (e − ) 和空穴 (h + )。体外和体内研究表明，工程化的单原子掺杂纳米声敏剂有效地实现了TNBC的显着抑制效果，通过基于声/化学纳米动力疗法的相互过程，为非侵入性和安全消除肿瘤提供了治疗范例。多功能单原子纳米声敏剂的研究。
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