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Macrostines A and B: Tetracyclic fisicoccane from the fungus Periconia macrospinosa WTG-10
Fitoterapia ( IF 2.5 ) Pub Date : 2023-01-14 , DOI: 10.1016/j.fitote.2023.105429 Bing-Xian Li 1 , Yan Shu 1 , Sheng-Qi Zhang 1 , Rui-Dang Yang 1 , Lin-Lin Yao 1 , Jia-Qi Liu 1 , Shuai-Xing Liu 1 , Jia-Peng Wang 2 , Le Cai 1
更新日期：2023-01-14
Fitoterapia ( IF 2.5 ) Pub Date : 2023-01-14 , DOI: 10.1016/j.fitote.2023.105429 Bing-Xian Li 1 , Yan Shu 1 , Sheng-Qi Zhang 1 , Rui-Dang Yang 1 , Lin-Lin Yao 1 , Jia-Qi Liu 1 , Shuai-Xing Liu 1 , Jia-Peng Wang 2 , Le Cai 1
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Two previous unreported fusicoccane diterpenoids macrostines A and B, together with seven known compounds were isolated from an extract of the fungus Periconia macrospinosa WTG-10. Their structures were elucidated by detailed analysis of spectroscopic data, NMR calculations with DP4+, and their absolute configurations were further determined by quantum chemical calculations of ECD spectra or X-crystallography. Macrostines A and B showed no cytotoxicity, antimicrobial activity and inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages. Compound 9 showed moderate activity against Bacillus subtilis.
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