DMAPO/Boc2O-Mediated One-Pot Direct N-Acylation of Less Nucleophilic N-Heterocycles with Carboxylic Acids,ChemCatChem

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DMAPO/Boc2O-Mediated One-Pot Direct N-Acylation of Less Nucleophilic N-Heterocycles with Carboxylic Acids
ChemCatChem ( IF 3.8 ) Pub Date : 2023-01-13 , DOI: 10.1002/cctc.202201596
Atsushi Umehara ₁ , Soma Shimizu ₂ , Makoto Sasaki ₂

Affiliation

Nitrogen Nucleophiles: A general method for direct N-acylation of less nucleophilic nitrogen heterocycles with carboxylic acids is reported. The method, which uses simple, commercially available reagents, no metals and user-friendly conditions, shows excellent functional group tolerance and broad substrate scope for both nitrogen nucleophiles and carboxylic acids.

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