Bicyclobutanes are among the most highly strained isolable organic compounds and their associated low activation barriers to reactivity make them intriguing building-blocks in organic chemistry. In recent years, numerous creative synthetic strategies exploiting their heightened reactivity have been presented and these discoveries have often gone hand-in-hand with the development of more practical routes for their synthesis. Their proclivity as strain-release reagents through their weak central C–C bond has been harnessed in a variety of addition, rearrangement and insertion reactions, providing rapid access to a rich tapestry of complex molecular scaffolds. This review will provide an overview of the different options available for bicyclobutane synthesis, the main classes of compounds that can be prepared from bicyclobutanes, and the associated modes of reactivity used.

双环丁烷是最紧张的可分离有机化合物之一，它们相关的低反应性活化能垒使它们成为有机化学中令人感兴趣的组成部分。近年来，已经提出了许多利用其高反应性的创造性合成策略，并且这些发现通常与更实用的合成路线的开发齐头并进。它们通过弱中心 C-C 键作为应变释放试剂的倾向已被用于各种加成、重排和插入反应，提供了快速获得复杂分子支架的丰富挂毯。本综述将概述可用于双环丁烷合成的不同选择、可从双环丁烷制备的主要化合物类别、