The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate salt of naloxegol (a pharmaceutically acceptable salt). This novel route has a very high yield and purity greater than 99.5%, substantially free from impurities (less than 1%).

中文翻译：

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阿片受体拮抗剂草酸纳洛昔康的制备工艺改进

本文公开了现代药物纳洛昔康草酸盐的改进且稳健的商业化工艺，用于治疗阿片类药物引起的便秘。合成源自容易获得的关键原料，即纳洛酮，并以纳洛昔康的草酸盐（药学上可接受的盐）结束。这条新路线具有非常高的产率和大于 99.5% 的纯度，基本上不含杂质（小于 1%）。