铜钼硫化物 (Cu2MoS4) 纳米板作为一种熟练的电催化界面，用于增强氧氟沙星的电化学氧化还原信号，用于检测药物样品,New Journal of Chemistry

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铜钼硫化物 (Cu2MoS4) 纳米板作为一种熟练的电催化界面，用于增强氧氟沙星的电化学氧化还原信号，用于检测药物样品
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2023-01-10 , DOI: 10.1039/d2nj06098a
Thi Lan Huong Phung _{1,

2} , Ngoc Phan Vu _{1,

3} , Tuan Anh Nguyen ₁ , Ngoc Huyen Nguyen ₁ , Xuan Dinh Ngo ₁ , Van Hoi Bui ₄ , Ly T. Le ₄ , Anh D. Nguyen ₄ , Anh-Tuan Le _{1,

5}

Affiliation

将纳米催化剂引入电化学传感系统为开发具有高灵敏度、选择性和稳定性的先进电化学传感装置开辟了新的机会。_{在这项研究中，使用富含活性位点的 Cu 2} MoS ₄纳米板作为出色的电催化平台，开发了一种用于准确测定药物样品（即商用滴眼液）中氧氟沙星的新型电化学传感器。使用循环伏安法和扫描线性伏安法技术研究了Cu ₂ MoS ₄纳米板的电催化活性。获得的结果表明，Cu ₂ MoS ₄纳米片对氧氟沙星的电化学氧化表现出优异的电催化活性，从而促进了氧氟沙星的灵敏检测。_{Cu 2} MoS ₄ /SPE（丝网印刷电极）的氧氟沙星氧化峰电流响应比裸露的 SPE 高 2.65 倍。在最佳条件下，基于 Cu ₂ MoS ₄纳米板的电化学传感器表现出 0.625 至 100 μM 的线性范围，检测限 (LOD) 为 0.067 μM。重要的是，与 UPLC-MS/MS 分析（RSD < 3.89%）相比，所提出的传感器显示出出色的准确性，具有良好的抗干扰性、高稳定性和可重复性（RSD < 6.3%，n= 20）。所获得的结果证明了基于过渡金属硫族化物的电催化剂在开发先进的电化学传感器方面具有广阔的应用前景。

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Copper molybdenum sulfide (Cu2MoS4) nanoplates as a proficient electrocatalytic interface for enhancing the electrochemical redox signals of ofloxacin for detection in pharmaceutical samples

The introduction of nanocatalysts into electrochemical sensing systems has opened up new opportunities in developing advanced electrochemical sensing devices with high sensitivity, selectivity, and stability. In this study, a novel electrochemical sensor for the accurate determination of ofloxacin in a pharmaceutical sample (i.e., in commercial eye drops) was developed using active-site-rich Cu₂MoS₄ nanoplates as an excellent electrocatalytic platform. The electrocatalytic activity of the Cu₂MoS₄ nanoplates was investigated using cyclic voltammetry and sweep linear voltammetry techniques. The results obtained demonstrated that the Cu₂MoS₄ nanoplates exhibit a superior electrocatalytic activity toward the electrochemical oxidation of ofloxacin, thus promoting the sensitive detection of ofloxacin. The ofloxacin oxidation peak current response for Cu₂MoS₄/SPE (screen-printed electrode) was 2.65 times higher than that of the bare SPE. Under optimal conditions, the Cu₂MoS₄ nanoplate-based electrochemical sensor exhibited a linear range from 0.625 to 100 μM with a limit of detection (LOD) of 0.067 μM. Importantly, the proposed sensor showed excellent accuracy in comparison with UPLC-MS/MS analysis (RSD < 3.89%), with good interference immunity, high stability, and repeatability (RSD < 6.3%, n = 20). The obtained results demonstrate the promising applications of transition metal chalcogenide-based electrocatalysts in developing advanced electrochemical sensors.

更新日期：2023-01-10

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