<br>载脂蛋白与脂质纳米颗粒的相互作用,ACS Nano

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载脂蛋白与脂质纳米颗粒的相互作用
ACS Nano ( IF 15.8 ) Pub Date : 2023-01-09 , DOI: 10.1021/acsnano.2c10790
Paul Dalhaimer ₁ , Brice Florey ₁ , Sami Isaac ₁

Affiliation

血清蛋白与注射到哺乳动物脉管系统中的纳米颗粒 (NP) 结合并形成动态蛋白冠。多项基础研究表明，载脂蛋白是 NP 冠的重要组成部分。由于载脂蛋白控制脂蛋白的分布，因此它们也可能控制纳米颗粒的分布。事实上，载脂蛋白对 NP 的亲和力最近已被利用，将封装在 NP 中的 CRISPR 试剂递送至表达特定脂蛋白受体的细胞。在这种情况下，载脂蛋白与 NP 结合，所得载脂蛋白-NP 复合物与表达 (apo) 脂蛋白受体的细胞结合。但如果 NP 不表达 (apo) 脂蛋白受体，它就会从靶细胞转移。这可能会妨碍 NP 对疾病的治疗。因此，我们必须了解载脂蛋白-NP 亲和力的动力学以及载脂蛋白-NP 相互作用如何影响 NP 生物分布。在这篇文章中，我们讨论了载脂蛋白-NP 相互作用这一不断发展的话题，这对于所有基于 NP 的疾病治疗都非常有意义。载脂蛋白-NP 复合物的许多特性尚未确定，并且将对动物模型和临床中许多基于 NP 的治疗的 NP 功效产生重大影响。

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Interactions of Apolipoproteins with Lipid-Based Nanoparticles

Serum proteins bind and form a dynamic protein corona around nanoparticles (NPs) that have been injected into the mammalian vasculature. Several fundamental studies have shown that apolipoproteins are prominent components of the NP corona. Since apolipoproteins control the distribution of lipoproteins, they may also control the distribution of NPs. Indeed, apolipoprotein affinity for NPs has been recently taken advantage of to deliver CRISPR reagents encapsulated in NPs to cells that express particular lipoprotein receptors. In this scenario, an apolipoprotein binds an NP and the resulting apolipoprotein-NP complex binds a cell that expresses the (apo)lipoprotein receptor. But the NP will be diverted from the target cell if it does not express the (apo)lipoprotein receptor. This may hamper NP treatment of diseases. Therefore, we must understand the kinetics of apolipoprotein-NP affinity and how apolipoprotein-NP interactions affect NP biodistribution. In this Perspective, we discuss the evolving topic of apolipoprotein-NP interactions, which is of great interest for all NP-based disease treatments. Many properties of apolipoprotein-NP complexes are yet to be determined and will have a significant impact on NP efficacy for many NP-based treatments in animal models and in the clinic.

更新日期：2023-01-09

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