菠萝蛋白酶的抗癌特性：最新技术和最新趋势,Frontiers in Oncology

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菠萝蛋白酶的抗癌特性：最新技术和最新趋势
Frontiers in Oncology ( IF 3.5 ) Pub Date : 2023-01-10 , DOI: 10.3389/fonc.2022.1068778
Raffaele Pezzani _{1,

2} , Manuel Jiménez-Garcia ₃ , Xavier Capó ₄ , Eda Sönmez Gürer ₅ , Farukh Sharopov ₆ , Tchokouaha Yamthe Lauve Rachel ₇ , David Ntieche Woutouoba ₈ , Antonio Rescigno ₉ , Stefania Peddio ₉ , Paolo Zucca ₉ , Patrick Valere Tsouh Fokou ₁₀ , Miquel Martorell _{11,

12} , Zehra Gulsunoglu-Konuskan ₁₃ , Alibek Ydyrys _{14,

15} , Tynybekov Bekzat ₁₆ , Tussupbekova Gulmira ₁₇ , Christophe Hano ₁₈ , Javad Sharifi-Rad ₁₉ , Daniela Calina ₂₀

Affiliation

Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy.
Associazione Italiana per la Ricerca Oncologica di Base (AIROB), Padova, Italy.
Laboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Palma de Mallorca, Spain.
Research Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands, Palma de Mallorca, Spain.
Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey.
Research Institution "Chinese-Tajik Innovation Center for Natural Products" of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan.
Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon.
Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde, Yaounde, Cameroon.
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon.
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, Chile.
Faculty of Health Science, Nutrition and Dietetics Department, Istanbul Aydin University, Istanbul, Turkey.
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
The Elliott School of International Affairs, George Washington University, Washington, DC, United States.
Department of Biodiversity and Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Department of Biological Chemistry, University of Orleans, Chartres, France.
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

菠萝蛋白酶是菠萝中发现的一种关键酶（凤梨 (L.) Merr.); 一种蛋白水解物质，对人类健康具有多种有益作用，例如抗炎、免疫调节、抗氧化和抗癌作用，传统上因其潜在的治疗价值而在许多国家使用。这篇更新的综合综述的目的是关注菠萝蛋白酶的潜在抗癌益处，分析癌细胞和动物模型中的细胞毒性、凋亡、坏死、自噬、免疫调节和抗炎作用。从 PubMed/MedLine、TRIP 数据库、GeenMedical、Scopus、Web of Science 和 Google Scholar 等在线数据库收集了有关菠萝蛋白酶及其在细胞、分子和信号水平的抗癌作用的详细信息。分析研究的结果表明，菠萝蛋白酶具有确凿的药理活性，如抗癌、抗水肿、抗炎、抗微生物、抗凝血、抗骨关节炎、抗外伤止痛、止泻、伤口修复。尽管如此，菠萝蛋白酶的临床研究很少，还需要更多的研究来验证这种酶在人类癌症疾病中的科学价值。

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更新日期：2023-01-10

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