This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds, such as isoxazole and cytisine. It has been demonstrated that the reaction led to the single-stage method under very mild conditions to obtain 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. This class of compounds is promising for obtaining the new biologically active compounds. This article has examined, in detail, a structure with using the 1H and 13C NMR and two-dimensional NMR spectroscopy of COSY (1H-1H), HMQC (1H-13C) and HMBC (1H-13C). As a result, the homo- and heteronuclear spin-spin couplings should be established. The X-ray diffraction analysis has determined the spatial structure of a new derivative based on the cytisine alkaloid. Thus, its hemorheological activity has been studied.

中文翻译：

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4-[(3,5-二甲基-1,2-恶唑-4-基)磺酰基]金雀花碱的合成、性质和空间结构。

本文研究了已知生物碱金雀花碱的新衍生物的合成，金雀花碱包含在 Cytisus laburnum L. 和 Thermopsis lanceolata R.Br.（Lugiminosae 家族）植物的种子中。这种新化合物是从异恶唑和金雀花碱等两种具有生物活性的化合物中获得的。已经证明，该反应导致在非常温和的条件下采用单阶段方法获得 4-[(3,5-二甲基-1,2-恶唑-4-基)磺酰基]金雀花碱。这类化合物有望获得新的生物活性化合物。本文使用 COSY (1H-1H)、HMQC (1H-13C) 和 HMBC (1H-13C) 的 1H 和 13C NMR 以及二维 NMR 光谱详细检查了结构。因此，应该建立同核和异核自旋-自旋偶联。X 射线衍射分析确定了一种基于金雀花生物碱的新衍生物的空间结构。因此，对其血液流变学活性进行了研究。