用于肿瘤靶向联合化疗/光疗的 pH/ROS 双响应纳米粒子系统,New Journal of Chemistry

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用于肿瘤靶向联合化疗/光疗的 pH/ROS 双响应纳米粒子系统
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2023-01-07 , DOI: 10.1039/d2nj05078a
Ying Luo ₁ , Yiyang Cong ₂ , Jia Liu ₁ , Lihua Huang ₁ , Wanting Cheng ₁ , Peihu Xu ₁ , Yihua Yin ₁ , Hao Hong ₂ , Wenjin Xu ₁

Affiliation

基于纳米级金属有机框架（nMOF）的纳米药物递送系统在生物医学领域显示出巨大的潜力。在这项工作中，设计了一种结合化疗和光疗的药物递送系统（DOX/ICG@UiO-66-TK-PEG-F3 或简化为 DI@UiO-TPF3）用于肿瘤的靶向治疗。化疗药物多柔比星（DOX）和光热治疗剂吲哚菁绿（ICG）通过物理吸附负载到pH敏感的UiO-66-NH ₂载体核上，UiO-66-NH _2表面被多功能聚合物 TK-PEG-F3 修饰，以提高载药核心的稳定性和靶向性。表征表明，成功制备了具有优异载药率（21.6%）和光热转换效率（32.92%）的药物递送系统DI@UiO-TPF3。DI@UiO-TPF3不仅表现出刺激反应释放药物的能力，而且实现了化学疗法和光热/光动力疗法（PTT/PDT）的协同抗肿瘤作用，这在体外得到证实评估。此外，细胞实验证实，连接F3肽的DI@UiO-TPF3可选择性结合肿瘤细胞表面过表达的核仁素，降低对正常细胞的毒性。因此，DI@UiO-UTPF3为构建化疗光疗一体化的靶向给药平台提供了一种可行的策略。

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A pH/ROS dual-responsive nanoparticle system for tumor targeting combined chemotherapy/phototherapy

Nanoscale metal–organic framework (nMOF) based nano drug delivery systems show great potential in the biomedical field. In this work, a drug delivery system combined with chemotherapy and phototherapy (DOX/ICG@UiO-66-TK-PEG-F3 or simplified as DI@UiO-TPF3) was designed for the targeted therapy of tumors. The chemotherapeutic drug doxorubicin (DOX) and the photothermal therapeutic agent indocyanine green (ICG) were loaded onto the pH-sensitive UiO-66-NH₂ carrier core by physical adsorption, and the surface of UiO-66-NH₂ was modified by the multifunctional polymer TK-PEG-F3 to improve the stability and targeting of the drug-loaded core. Characterizations show that the drug delivery system DI@UiO-TPF3 was successfully prepared with an excellent drug loading rate (21.6%) and photothermal conversion efficiency (32.92%). DI@UiO-TPF3 not only shows the ability to stimulate a response to release drugs, but also achieves the synergistic anti-tumor effects of chemotherapy and photothermal/photodynamic therapy (PTT/PDT), which was confirmed by in vitro evaluation. In addition, cell experiments have confirmed that DI@UiO-TPF3 connected with F3 peptide can selectively bind to the nucleolin overexpressed on the surface of tumor cells and reduce the toxicity to normal cells. Therefore, DI@UiO-UTPF3 provided a feasible strategy for constructing a targeted drug delivery platform integrating chemotherapy and phototherapy.

更新日期：2023-01-07

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