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Injectable Tissue-Adhesive Hydrogel for Photothermal/Chemodynamic Synergistic Antibacterial and Wound Healing Promotion
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-01-05 , DOI: 10.1021/acsami.2c19566 Han Huang 1 , Yan Su 1 , Chenxi Wang 1 , Bing Lei 2 , Xuejiao Song 1 , Wenjun Wang 2 , Pan Wu 3 , Xiyu Liu 3 , Xiaochen Dong 1, 4 , Liping Zhong 3
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-01-05 , DOI: 10.1021/acsami.2c19566 Han Huang 1 , Yan Su 1 , Chenxi Wang 1 , Bing Lei 2 , Xuejiao Song 1 , Wenjun Wang 2 , Pan Wu 3 , Xiyu Liu 3 , Xiaochen Dong 1, 4 , Liping Zhong 3
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It is an exigent need for the development of hydrogel dressings with desirable injectability, good adhesive, antibacterial, and wound healing promotion properties. Herein, the multifunctional injectable hydrogels with good tissue adhesion are designed based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, and tea polyphenols (TPs) for antibacterial and wound healing acceleration. After being injected into the tissue, urea diffuses out under the concentration gradient, and TPs and gelatin chains recombine to trigger the in situ formation of hydrogel with excellent adhesiveness. AgPOM fixed in the hydrogel could not only react with hydrogen peroxide in the infection site to generate singlet oxygen to kill the bacteria but also convert near-infrared light into heat under 1060 nm laser irradiation to realize sterilization. In vitro studies display the high bactericidal ability of the hydrogel against drug-resistant Staphylococcus aureus and also exhibit a prominent therapeutic effect on infected wounds through synergistic photothermal/chemodynamic therapy and accelerate wound healing. Hence, the injectable hydrogel with AgPOM as the antimicrobial agent can be a novel therapeutic agent for drug-resistant bacteria-infected wounds and wound healing promotion.
中文翻译：
用于光热/化学动力学协同抗菌和促进伤口愈合的可注射组织粘附水凝胶
迫切需要开发具有良好可注射性、良好粘附性、抗菌性和促进伤口愈合性能的水凝胶敷料。在此，基于Ag掺杂的Mo 2设计了具有良好组织粘附性的多功能可注射水凝胶C 衍生的多金属氧酸盐 (AgPOM) 纳米颗粒、尿素、明胶和茶多酚 (TP) 用于抗菌和加速伤口愈合。注入组织后，尿素在浓度梯度下扩散出去，TPs和明胶链重新结合，引发原位形成具有优异粘附性的水凝胶。固定在水凝胶中的 AgPOM 不仅可以在感染部位与过氧化氢反应生成单线态氧来杀死细菌，还可以在 1060 nm 激光照射下将近红外光转化为热能实现杀菌。体外研究表明水凝胶对耐药金黄色葡萄球菌具有高杀菌能力并且还通过协同光热/化学动力学疗法对感染伤口表现出显着的治疗效果并加速伤口愈合。因此，以 AgPOM 作为抗菌剂的可注射水凝胶可以成为耐药细菌感染伤口和促进伤口愈合的新型治疗剂。
更新日期：2023-01-05
中文翻译：
用于光热/化学动力学协同抗菌和促进伤口愈合的可注射组织粘附水凝胶
迫切需要开发具有良好可注射性、良好粘附性、抗菌性和促进伤口愈合性能的水凝胶敷料。在此，基于Ag掺杂的Mo 2设计了具有良好组织粘附性的多功能可注射水凝胶C 衍生的多金属氧酸盐 (AgPOM) 纳米颗粒、尿素、明胶和茶多酚 (TP) 用于抗菌和加速伤口愈合。注入组织后，尿素在浓度梯度下扩散出去，TPs和明胶链重新结合，引发原位形成具有优异粘附性的水凝胶。固定在水凝胶中的 AgPOM 不仅可以在感染部位与过氧化氢反应生成单线态氧来杀死细菌，还可以在 1060 nm 激光照射下将近红外光转化为热能实现杀菌。体外研究表明水凝胶对耐药金黄色葡萄球菌具有高杀菌能力并且还通过协同光热/化学动力学疗法对感染伤口表现出显着的治疗效果并加速伤口愈合。因此，以 AgPOM 作为抗菌剂的可注射水凝胶可以成为耐药细菌感染伤口和促进伤口愈合的新型治疗剂。
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