Unprecedented long-term survival in a patient with malignant pleural mesothelioma treated with subsequent systemic chemo- and immunotherapeutic regimens,Thoracic Cancer

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Unprecedented long-term survival in a patient with malignant pleural mesothelioma treated with subsequent systemic chemo- and immunotherapeutic regimens
Thoracic Cancer ( IF 2.3 ) Pub Date : 2023-01-04 , DOI: 10.1111/1759-7714.14789
Luigi Cerbone ₁ , Sara Delfanti ₁ , Antonina M De Angelis ₁ , Stefania Crivellari ₂ , Francesco Boccuzzi ₃ , Angela Cimorelli ₁ , Marinella Bertolotti ₂ , Luisella Righi ₄ , Pietro Bertino _{2,

5} , Federica Grosso ₁

Affiliation

Pleural mesothelioma is a rare disease with a dismal prognosis and few therapeutic options. Until recently the median overall survival for a pleural mesothelioma patient was up to 2 years, with few exceptional cases of patients achieving a longer survival. Here, we report the clinical case of a patient whose survival spanned over 10 years. The patient underwent several systemic treatments, including three different chemotherapy lines (cisplatin-pemetrexed, vinorelbine and platinum rechallenge) and two immunotherapy regimens using immune checkpoint inhibitors (anti CTLA-4 tremelimumab and anti PD-1 nivolumab). At the time this report was written, the patient was off-treatment, asymptomatic and with a stable radiological disease. Our case demonstrates that a prolonged survival with a preserved quality of life may be reached in selected patients through the exploitation of the available treatments in an expertise setting.

中文翻译：

恶性胸膜间皮瘤患者接受后续全身化疗和免疫治疗方案后的长期生存史无前例

胸膜间皮瘤是一种罕见的疾病，预后不佳且治疗选择很少。直到最近，胸膜间皮瘤患者的中位总生存期才长达 2 年，只有极少数例外情况的患者能获得更长的生存期。在这里，我们报告了一名存活超过 10 年的患者的临床病例。该患者接受了多种全身治疗，包括三种不同的化疗方案（顺铂-培美曲塞、长春瑞滨和铂类再激发）和两种使用免疫检查点抑制剂的免疫治疗方案（抗 CTLA-4 tremelimumab 和抗 PD-1 nivolumab）。在撰写本报告时，患者已停止治疗、无症状且放射学疾病稳定。

更新日期：2023-01-04

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