Immunomodulation with Nucleic Acid Nanodevices,Small

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Immunomodulation with Nucleic Acid Nanodevices
Small ( IF 13.0 ) Pub Date : 2023-01-04 , DOI: 10.1002/smll.202206228
Fei Ding ₁ , Shuangye Zhang ₂ , Qian Chen ₁ , Hao Feng ₁ , Zhilei Ge ₂ , Xiaolei Zuo _{1,

2} , Chunhai Fan ₂ , Qian Li _{2,

3} , Qiang Xia ₁

Affiliation

The precise regulation of interactions of specific immunological components is crucial for controllable immunomodulation, yet it remains a great challenge. With the assistance of advanced computer design, programmable nucleic acid nanotechnology enables the customization of synthetic nucleic acid nanodevices with unprecedented geometrical and functional precision, which have shown promising potential for precise immunoengineering. Notably, the inherently immunologic functions of nucleic acids endow these nucleic acid-based assemblies with innate advantages in immunomodulatory engagement. In this review, the roles of nucleic acids in innate immunity are discussed, focusing on the definition, immunologic modularity, and enhanced bioavailability of structural nucleic acid nanodevices. In light of this, molecular programming and precise organization of functional modules with nucleic acid nanodevices for immunomodulation are emphatically reviewed. At last, the present challenges and future perspectives of nucleic acid nanodevices for immunomodulation are discussed.

中文翻译：

核酸纳米器件的免疫调节

精确调节特定免疫成分的相互作用对于可控免疫调节至关重要，但它仍然是一个巨大的挑战。借助先进的计算机设计，可编程核酸纳米技术能够定制具有前所未有的几何和功能精度的合成核酸纳米器件，这在精确免疫工程方面显示出巨大的潜力。值得注意的是，核酸固有的免疫功能赋予这些基于核酸的组装体在免疫调节参与方面的先天优势。在这篇综述中，讨论了核酸在先天免疫中的作用，重点关注结构核酸纳米器件的定义、免疫模块化和增强的生物利用度。有鉴于此，重点回顾了用于免疫调节的核酸纳米器件功能模块的分子编程和精确组织。最后，讨论了用于免疫调节的核酸纳米器件目前面临的挑战和未来前景。

更新日期：2023-01-04

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