基于活性氧 (ROS) 的动态癌症疗法是内源性/外源性响应瘤内 ROS 生成的治疗方式,包括光动力疗法 (PDT)、声动力疗法 (SDT)、放射动力疗法 (RDT)、电动力疗法 (EDT)、化学动力学疗法(CDT)和微波动力疗法(MDT)。数十项临床前和临床证据表明,ROS 操纵的动态疗法可有效促进肿瘤消退。然而,这些动态治疗策略面临着主要障碍,包括外源性或内源性刺激供应不足、脱靶引发剂的潜在毒性以及深部实体瘤的治疗结果不佳。随着生物医学纳米技术的飞速发展,已经建立了各种癌症动态治疗纳米平台来诱导 ROS 的产生,以高选择性、安全性和非侵入性的方式治疗难治性肿瘤。本综述概述了基于 ROS 的基本机制和动态疗法的当前临床状态。我们总结了纳米技术辅助动态疗法的最新进展,包括它们的优势、单一的动态纳米抗癌应用,以及各种动态纳米治疗方式的协同效应。此外,还讨论了潜在的挑战和前景。本综述描述了基于 ROS 的动态纳米疗法的优势,旨在释放 ROS 的内在力量以优化治疗效果。本综述概述了基于 ROS 的基本机制和动态疗法的当前临床状态。我们总结了纳米技术辅助动态疗法的最新进展,包括它们的优势、单一的动态纳米抗癌应用,以及各种动态纳米治疗方式的协同作用。此外,还讨论了潜在的挑战和前景。本综述描述了基于 ROS 的动态纳米疗法的优势,旨在释放 ROS 的内在力量以优化治疗效果。本综述概述了基于 ROS 的基本机制和动态疗法的当前临床状态。我们总结了纳米技术辅助动态疗法的最新进展,包括它们的优势、单一的动态纳米抗癌应用,以及各种动态纳米治疗方式的协同作用。此外,还讨论了潜在的挑战和前景。本综述描述了基于 ROS 的动态纳米疗法的优势,旨在释放 ROS 的内在力量以优化治疗效果。此外,还讨论了潜在的挑战和前景。本综述描述了基于 ROS 的动态纳米疗法的优势,旨在释放 ROS 的内在力量以优化治疗效果。此外,还讨论了潜在的挑战和前景。本综述描述了基于 ROS 的动态纳米疗法的优势,旨在释放 ROS 的内在力量以优化治疗效果。
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Nano-ROS-generating approaches to cancer dynamic therapy: Lessons from Nanoparticles
Reactive oxygen species (ROS)-based dynamic cancer therapies are therapeutic modalities of endogenous/exogenous-responsive intratumoral ROS generation, including photodynamic therapy (PDT), sonodynamic therapy (SDT), radiation dynamic therapy (RDT), electrodynamic therapy (EDT), chemodynamic therapy (CDT) and microwave dynamic therapy (MDT). Dozens of pre-clinical and clinical evidences indicate that ROS-manipulated dynamic therapies effectively promote tumor regression. However, these dynamic therapeutic strategies face major obstacles, containing an insufficient supply of exogenous or endogenous stimulation, the potential toxicity of off-target initiators, and poor treatment outcome amongst deep solid tumors. With the rapid progress of biomedical nanotechnology, various cancer dynamic therapeutic nanoplatforms have been established to induce ROS production for treating a refractory tumor with high selectivity, safety, and non-invasiveness. This review outlines ROS-based fundamental mechanisms and the current clinical status of dynamic therapies. We summarize the recent advances of nanotechnology-assisted dynamic therapies in their superiority, single dynamic nano-applications against cancers, and synergistic effects of various dynamic nano-therapeutic modalities. Moreover, potential challenges and prospects have also been discussed. This review describes the advantages of ROS-based dynamic nano-therapies, aiming to release the inherent power of ROS for optimizing treatment effects.