Synthesis ( IF 2.2 ) Pub Date : 2023-01-03 , DOI: 10.1055/s-0042-1751402 Rui Wang 1, 2 , You F. Gan 1 , Yuan Y. Li 1 , Xiao Q. Chen 1 , Yu Y. Guo 1
Here we summarize the most recent findings in the chemical-, photo-, or enzyme-triggered generation of nitrogen and oxygen anions leading to the formation of quinone methide intermediates (QMIs). This short review is divided into two categories: generation of nitrogen and oxygen anions. Based on quinone methide intermediates (QMIs), proximate capture of a wide range of proteins has been widely determined and studied. Generally, the triggers include, photoirradiation using 365/254 nm UV light, small molecules (ROS/TBAF/s-tetrazine), metal catalysis (iridium catalysis), and enzymes (NQO1/β-galactosidase). New directions including far-red light, heat, force, microwave, and more practical approaches are explored and illustrated.
1 Introduction
2 Generation of the Nitrogen Anion
3 Generation of the Oxygen Anion
4 Conclusion
中文翻译:
用于蛋白质邻近捕获的醌甲基化物化学的最新进展
在这里,我们总结了化学、光或酶触发的氮和氧阴离子生成导致醌甲基化物中间体 (QMI) 形成的最新发现。这篇简短的评论分为两类:氮和氧阴离子的产生。基于醌甲基化物中间体 (QMI),广泛确定和研究了多种蛋白质的近似捕获。通常,触发因素包括使用 365/254 nm 紫外光的光照射、小分子(ROS/TBAF/ s-四嗪)、金属催化(铱催化)和酶(NQO1/β-半乳糖苷酶)。探索和说明了新方向,包括远红光、热、力、微波和更实用的方法。
1 简介
2 氮负离子的产生
3 氧负离子的产生
4。结论