The chemoselective C–C bond cleavage of bicyclo[1.1.1]pent-1-yl alcohols (BCP-OHs) was examined. Highly ring-strained BCP-OHs were found to be particularly reactive, delivering cyclobutanone derivatives through a base-mediated single C–C bond cleavage or α,β-unsaturated ketones by palladium-catalyzed dual C–C bond cleavage.

中文翻译：

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双环[1.1.1]戊-1-醇的化学选择性应变释放

检查了双环[1.1.1]戊-1-醇 (BCP-OH) 的化学选择性 C-C 键裂解。发现高度环应变的 BCP-OH 具有特别的反应性，通过碱介导的单 C-C 键裂解产生环丁酮衍生物，或通过钯催化的双 C-C 键裂解产生 α,β-不饱和酮。