Chloroacetate esterase reaction combined with immunohistochemical characterization of the specific tissue microenvironment of mast cells,Histochemistry and Cell Biology

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Chloroacetate esterase reaction combined with immunohistochemical characterization of the specific tissue microenvironment of mast cells
Histochemistry and Cell Biology ( IF 2.1 ) Pub Date : 2023-01-04 , DOI: 10.1007/s00418-022-02174-1
Dmitri Atiakshin _{1,

2} , Andrey Kostin ₁ , Igor Buchwalow _{1,

3} , Denis Morozow ₃ , Vera Samoilova ₃ , Markus Tiemann ₃

Affiliation

This study provides a combined histochemical method for detecting enzyme activity of chloroacetate esterase simultaneously with immunolabeling of the components of a specific tissue microenvironment on formalin-fixed, paraffin-embedded specimens. Chromogenic detection of the molecular targets within and outside the mast cells provides novel options in determining the histoarchitectonics of organ-specific mast cell populations, studying the functional significance of chloroacetate esterase and specifying the immune landscape of the tissue microenvironment.

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