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2(1H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations
RSC Advances ( IF 3.9 ) Pub Date : 2023-01-04 , DOI: 10.1039/d2ra07227k Gerard Riesco-Llach 1 , Marta Planas 1 , Lidia Feliu 1 , John A Joule 2
RSC Advances ( IF 3.9 ) Pub Date : 2023-01-04 , DOI: 10.1039/d2ra07227k Gerard Riesco-Llach 1 , Marta Planas 1 , Lidia Feliu 1 , John A Joule 2
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Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021.
中文翻译：
来自无环结构单元的 2(1H)-吡嗪酮：合成和进一步衍生化的方法
吡嗪酮 (2(1 H )-吡嗪酮) 是一系列天然物质的组成部分，并参与大量生物活性分子的制备。此类化合物和类似物的合成需要了解吡嗪酮的杂环性质，特别是其环构建方法。本综述讨论了从 1905 年的第一个例子到 2021 年的最新例子，从无环前体（尤其是 α-氨基酸衍生单元）合成吡嗪酮的策略。
更新日期：2023-01-04
中文翻译：
来自无环结构单元的 2(1H)-吡嗪酮：合成和进一步衍生化的方法
吡嗪酮 (2(1 H )-吡嗪酮) 是一系列天然物质的组成部分，并参与大量生物活性分子的制备。此类化合物和类似物的合成需要了解吡嗪酮的杂环性质，特别是其环构建方法。本综述讨论了从 1905 年的第一个例子到 2021 年的最新例子，从无环前体（尤其是 α-氨基酸衍生单元）合成吡嗪酮的策略。
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