Nanoformulation of Lipophilic Osmium Photosensitizers in Liposomes and Micelles as a General Strategy for Improving Reproducibility and Reducing Quenching†,Photochemistry and Photobiology

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Nanoformulation of Lipophilic Osmium Photosensitizers in Liposomes and Micelles as a General Strategy for Improving Reproducibility and Reducing Quenching†
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2023-01-01 , DOI: 10.1111/php.13776
Elizabeth T. Papish ₁

Affiliation

Nanoformulation of an osmium photosensitizer within liposomes and micelles is used to improve the water-solubility of this highly lipophilic molecule. This highlight report describes a recent paper by Cameron, Obaid and McFarland on this topic and discusses the context for this report. Nanoformulation has been explored as a strategy before, but this represents the first usage of this strategy with highly potent metal-based photosensitizers having phototherapeutic indices (PIs) in excess of 10⁴. The nanoformulation strategy is effective due to reducing aggregation and self-quenching of the photosensitizer molecules.

中文翻译：

脂质体和胶束中亲脂性锇光敏剂的纳米制剂作为提高重现性和减少猝灭的一般策略†

脂质体和胶束内的锇光敏剂的纳米制剂用于改善这种高度亲脂性分子的水溶性。本重点报告介绍了 Cameron、Obaid 和 McFarland 最近就此主题发表的一篇论文，并讨论了本报告的背景。纳米制剂以前曾作为一种策略进行过探索，但这代表了该策略首次用于光治疗指数 (PI) 超过 10 4 的高效金属基^光敏剂。由于减少了光敏剂分子的聚集和自淬灭，纳米制剂策略是有效的。

更新日期：2023-01-01

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