Detailed radiosynthesis of [18F]mG4P027 as a positron emission tomography radiotracer for mGluR4,Journal of Labelled Compounds and Radiopharmaceuticals

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Detailed radiosynthesis of [18F]mG4P027 as a positron emission tomography radiotracer for mGluR4
Journal of Labelled Compounds and Radiopharmaceuticals ( IF 0.9 ) Pub Date : 2023-01-02 , DOI: 10.1002/jlcr.4011
Junfeng Wang ₁ , Sung-Hyun Moon ₁ , Michael B Cleary ₂ , Timothy M Shoup ₁ , Georges El Fakhri ₁ , Zhaoda Zhang ₂ , Anna-Liisa Brownell ₁

Affiliation

We report here the detailed radiosynthesis of [¹⁸F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.

中文翻译：

[18F]mG4P027 作为 mGluR4 正电子发射断层扫描放射性示踪剂的详细放射合成

我们在此报告了 [ ¹⁸ F] mG4P027的详细放射合成，这是一种代谢型谷氨酸受体 4 (mGluR4) PET 放射性示踪剂，其显示出优于目前报道的 mGluR4 放射性示踪剂的特性。自动化系统中的放射合成一直具有挑战性，因此我们在此通过逐步检查公开了合成的主要限制因素。我们希望这项彻底的研究将有助于其未来的自动化供人类使用。

更新日期：2023-01-02

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