Pharmacokinetics of ginkgolide B–lyophilized nanoparticles after intravenous injection in rats using liquid chromatography–tandem mass spectrometry,Rapid Communications in Mass Spectrometry

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Pharmacokinetics of ginkgolide B–lyophilized nanoparticles after intravenous injection in rats using liquid chromatography–tandem mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2022-12-29 , DOI: 10.1002/rcm.9465
Lisha Ma _{1,

2} , Lujia Zhu _{1,

3} , Jianan Peng ₁ , Shujun Xu ₁ , Yue Zhao ₁ , Jingbin Shi ₁ , Qi Liu ₄ , Hui Zhang ₅ , Jun Li ₅ , Yang Xiong _{1,

2}

Affiliation

Ginkgolide B (GB) performs diverse pharmacological activities but has poor water solubility. The currently available GB injections have a short half-life and are lethal when injected rapidly. We prepared GB-lyophilized nanoparticles (GB-NPs) using a new nonsurfactant polysaccharide polymer, ZY-010, as its carrier to regulate the release of GB in vivo. Here, the pharmacokinetics (PK) of GB-NPs after intravenous injection in rats was performed using liquid chromatography–tandem mass spectrometry (LC–MS/MS).

中文翻译：

液相色谱-串联质谱法研究大鼠静脉注射银杏内酯 B 冻干纳米粒的药代动力学

银杏内酯 B (GB) 具有多种药理活性，但水溶性较差。目前可用的 GB 注射剂半衰期短，快速注射时是致命的。我们使用一种新型非表面活性剂多糖聚合物 ZY-010 作为载体制备 GB 冻干纳米颗粒 (GB-NPs)，以调节 GB在体内的释放。在此，使用液相色谱-串联质谱法 (LC-MS/MS) 对大鼠静脉注射后 GB-NPs 的药代动力学 (PK) 进行了分析。

更新日期：2022-12-29

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