An Ultrasound-Driven Bioadhesive Triboelectric Nanogenerator for Instant Wound Sealing and Electrically Accelerated Healing in Emergencies,Advanced Materials

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An Ultrasound-Driven Bioadhesive Triboelectric Nanogenerator for Instant Wound Sealing and Electrically Accelerated Healing in Emergencies
Advanced Materials ( IF 27.4 ) Pub Date : 2022-12-27 , DOI: 10.1002/adma.202209054
Xiangchun Meng ₁ , Xiao Xiao ₁ , Sera Jeon ₁ , Dabin Kim ₁ , Byung-Joon Park ₁ , Young-Jun Kim ₁ , Najaf Rubab ₁ , SeongMin Kim ₁ , Sang-Woo Kim _{1,

2}

Affiliation

A bioadhesive triboelectric nanogenerator (BA-TENG), as a first-aid rescue for instant and robust wound sealing and ultrasound-driven accelerated wound healing, is designed. This BA-TENG is fabricated with biocompatible materials, and integrates a flexible TENG as the top layer and bioadhesive as the bottom layer, resulting in effective electricity supply and strong sutureless sealing capability on wet tissues. When driven by ultrasound, the BA-TENG can produce a stable voltage of 1.50 V and current of 24.20 µA underwater. The ex vivo porcine colon organ models show that the BA-TENG seals defects instantly (≈5 s) with high interfacial toughness (≈150 J m⁻²), while the rat bleeding liver incision model confirms that the BA-TENG performs rapid wound closure and hemostasis, reducing the blood loss by about 82%. When applied in living rats, the BA-TENG not only seals skin injuries immediately but also produces a strong electric field (E-field) of about 0.86 kV m⁻¹ stimulated by ultrasound to accelerate skin wound healing significantly. The in vitro studies confirm that these effects are attributed to the E-field-accelerated cell migration and proliferation. In addition, these TENG adhesives can be applied to not only wound treatment, nerve stimulation and regeneration, and charging batteries in implanted devices.

中文翻译：

用于紧急情况下即时伤口密封和电加速愈合的超声驱动生物粘附摩擦纳米发电机

设计了一种生物粘附摩擦纳米发电机 (BA-TENG)，作为即时和稳健伤口密封和超声驱动的加速伤口愈合的急救。这种 BA-TENG 采用生物相容性材料制成，将柔性 TENG 作为顶层，将生物粘合剂作为底层，从而实现有效的电力供应和强大的湿组织无缝合密封能力。当由超声波驱动时，BA-TENG 可以在水下产生 1.50 V 的稳定电压和 24.20 µA 的电流。离体猪结肠器官模型表明，BA-TENG 可立即（≈5 s）密封缺陷，具有高界面韧性（≈150 J m ⁻²)，而大鼠出血肝切口模型证实BA-TENG进行快速伤口闭合和止血，减少约82%的失血量。^{当应用于活体大鼠时，BA-TENG 不仅可以立即封闭皮肤损伤，而且可以在超声波刺激下产生约 0.86 kV m -1}的强电场（E-field），显着加速皮肤伤口愈合。体外研究证实，这些效应归因于电场加速的细胞迁移和增殖。此外，这些 TENG 粘合剂不仅可以应用于伤口处理、神经刺激和再生以及植入设备中的电池充电。

更新日期：2022-12-27

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