载有维生素 E 的物理交联聚乙烯醇/壳聚糖/黄芪胶水凝胶用于伤口愈合应用,Journal of Vinyl and Additive Technology

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载有维生素 E 的物理交联聚乙烯醇/壳聚糖/黄芪胶水凝胶用于伤口愈合应用
Journal of Vinyl and Additive Technology ( IF 3.8 ) Pub Date : 2022-12-24 , DOI: 10.1002/vnl.21967
Parichehr Foroughi ₁ , Narjes Koupaei ₁

Affiliation

对于愈合过程，在这项研究中，通过冻融方法生产了一种创新的聚合物水凝胶网络，包括载有维生素 E (VE) 的聚乙烯醇 (PVA)/壳聚糖 (CS)/黄芪胶 (GT)。为了研究所制备样品的特性，进行了傅里叶变换红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 分析。此外，还测量了水蒸气透过率 (WVTR)、溶胀比、凝胶分数和机械性能。然后，为了观察它们的细胞相容性，评估了 MTT 测定和细胞粘附研究。FTIR 的结果证实了水凝胶薄膜中存在 PVA、CS、GT 和 VE。此外，SEM 图像显示了冷冻和解冻方法在创建具有小而规则孔隙的光滑表面方面的效果。发现将 CS 和 GT 添加到 PVA 中可以提高水凝胶膜的溶胀率、凝胶分数、WVTR 和伸长率。此外，在检查样品的粘附性和细胞毒性时，证实了 PVA/CS/GT 水凝胶薄膜的无毒质量。最后，抗菌性能显示含有 GT 和 CS 的薄膜具有最大的抗菌活性。根据观察结果，负载 VE 的 PVA/CS/GT 水凝胶薄膜可用于伤口愈合应用。抗菌性能表明含有GT和CS的薄膜具有最大的抗菌活性。根据观察结果，负载 VE 的 PVA/CS/GT 水凝胶薄膜可用于伤口愈合应用。抗菌性能表明含有GT和CS的薄膜具有最大的抗菌活性。根据观察结果，负载 VE 的 PVA/CS/GT 水凝胶薄膜可用于伤口愈合应用。

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Physically crosslinked polyvinyl alcohol/chitosan/gum tragacanth hydrogels loaded with vitamin E for wound healing applications

For the healing process, in this study, an innovative polymeric hydrogel network including polyvinyl alcohol (PVA)/chitosan (CS)/gum tragacanth (GT) loaded with vitamin E (VE) was produced by the freeze–thaw approach. In order to investigate the characteristics of the prepared samples, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) analyzes were performed. Also, water vapor transmission rate (WVTR), swelling ratio, gel fraction and mechanical properties were measured. Then, to observe their cytocompatibility, MTT assay and cell adhesion studies were assessed. The results of FTIR confirmed the presence of PVA, CS, GT, and VE in hydrogel films. As well as, the SEM images showed the effect of the freezing and thawing method in creating a smooth surface with small and regular pores. It was found with adding the CS and GT to PVA improves swelling ratio, gel fraction, WVTR and elongation of hydrogel films. Further, in examining the adhesion and cytotoxicity of the samples, the non-toxic quiddity of the PVA/CS/GT hydrogel films was corroborated. In the end, the antibacterial properties revealed that the film containing GT and CS had the greatest antibacterial activity. According to the observed results, PVA/CS/GT hydrogel films loaded with VE can be good for wound healing applications.

更新日期：2022-12-24

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