Grapes are important sources of phenolics, which are recognized to possess high biological value. In this work, we evaluated the total phenol content (TPC), total anthocyanin content (TAC), antioxidant activity (AA) and volatile composition of unstudied seedless table grape varieties (i.e., Autumn Crisp and Pristine as white cultivars, Scarlotta and Crimson as red cultivars and Adora and Melody as black cultivars). As a result, Adora and Melody exhibited higher TPCs, TACs and AA, measured by the 2,2-diphenyl-2-picrylhydrazil (DPPH) and photochemiluminescence (PCL) assays, than the rest of the varieties. A comparison between the two black cultivars proved that Adora possessed higher TPC (62.70 mg GAE 100 g⁻¹), DPPH radical scavenging activity (IC₅₀ of 3.69 mg ml⁻¹) and PCL antiradical activity (72.14 µg Trolox ml⁻¹) than Melody (47.30 mg GAE 100 g⁻¹, IC₅₀ of 5.0 mg ml⁻¹ and 42.36 µg Trolox ml⁻¹, respectively). The volatile composition, determined by solid phase microextraction (SPME)–gas chromatography/mass spectrometry (GC/MS), indicated a similar qualitative aroma profile for all varieties. However, quantitative differences were measured among them, which were reflected in distinct sensory perception by sensorial testing. From these results, Adora was selected for its antioxidant properties and flavor characteristics.