Precise control over the structure of metal nanomaterials is important for developing advanced nanobiotechnology. Assembly methods of nanoparticles into structured blocks have been widely demonstrated recently. However, synthesis of nanocrystals with controlled, three-dimensional structures remains challenging. Here we show a directed crystallization of gold by a single DNA molecular regulator in a sequence-independent manner and its applications in three-dimensional topological controls of crystalline nanostructures. We anchor DNA onto gold nanoseed with various alignments to form gold nanocrystals with defined topologies. Some topologies are asymmetric including pushpin-, star- and biconcave disk-like structures, as well as more complex jellyfish- and flower-like structures. The approach of employing DNA enables the solution-based synthesis of nanocrystals with controlled, three-dimensional structures in a desired direction, and expands the current tools available for designing and synthesizing feature-rich nanomaterials for future translational biotechnology.

中文翻译：

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具有DNA定向形态的金纳米晶体。

精确控制金属纳米材料的结构对于发展先进的纳米生物技术很重要。近年来，已经广泛证明了将纳米颗粒组装成结构块的方法。然而，具有受控的三维结构的纳米晶体的合成仍然具有挑战性。在这里，我们显示了由单个DNA分子调节剂以序列独立的方式对金的直接结晶及其在晶体纳米结构的三维拓扑控制中的应用。我们将DNA锚定到具有各种比对的金纳米种子上，以形成具有定义拓扑的金纳米晶体。一些拓扑结构是不对称的，包括图钉形，星形和双凹形的盘状结构，以及更复杂的水母和花状结构。