钽元素在感染性骨缺损中的研究进展及应用,ACS Biomaterials Science & Engineering

当前位置： X-MOL 学术 › ACS Biomater. Sci. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

钽元素在感染性骨缺损中的研究进展及应用
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2022-12-23 , DOI: 10.1021/acsbiomaterials.2c00884
Hu Qian ₁ , Qingshuang Yao ₁ , Lanping Pi ₂ , Jun Ao ₁ , Pengfei Lei ₃ , Yihe Hu ₃

Affiliation

感染性骨缺损 (IBD) 造成重大的经济和心理负担，对临床骨科医生提出了巨大挑战。管理 IBD 的传统方法具有不可避免的缺点；因此，有必要开发新的功能化支架。钽 (Ta) 由于其良好的生物相容性和耐腐蚀性，已被广泛用于承重骨科植入物。然而，未修饰的Ta只能在结构上修复常见的骨缺损，不能满足IBD抑菌的临床需求。研究人员通过各种方法，包括表面涂层、合金化、微纳米结构修饰等，努力使 Ta 支架功能化以增强其抗菌活性。此外，多项研究已成功利用 Ta 修饰骨科支架以增强抗菌功能。这些研究显着扩展了 Ta 的应用范围。因此，本综述系统概述了Ta在IBD治疗中的基础和临床应用进展，重点介绍了Ta的抗菌特性、抑菌功能及其在骨科支架改造中的应用。本研究为研究人员提供了 Ta 在 IBD 治疗中应用的概述。其抑菌功能化及其在骨科支架改造中的应用。本研究为研究人员提供了 Ta 在 IBD 治疗中应用的概述。其抑菌功能化及其在骨科支架改造中的应用。本研究为研究人员提供了 Ta 在 IBD 治疗中应用的概述。

"点击查看英文标题和摘要"

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Infected bone defects (IBDs) cause significant economic and psychological burdens, posing a huge challenge to clinical orthopedic surgeons. Traditional approaches for managing IBDs possess inevitable shortcomings; therefore, it is necessary to develop new functionalized scaffolds. Tantalum (Ta) has been widely used in load-bearing orthopedic implants due to its good biocompatibility and corrosion resistance. However, undecorated Ta could only structurally repair common bone defects, which failed to meet the clinical needs of bacteriostasis for IBDs. Researchers have made great efforts to functionalize Ta scaffolds to enhance their antibacterial activity through various methods, including surface coating, alloying, and micro- and nanostructure modifications. Additionally, several studies have successfully utilized Ta to modify orthopedic scaffolds for enhanced antibacterial function. These studies remarkably extended the application range of Ta. Therefore, this review systematically outlines the advances in the fundamental and clinical application of Ta in the treatment of IBDs, focusing on the antibacterial properties of Ta, its functionalization for bacteriostasis, and its applications in the modification of orthopedic scaffolds. This study provides researchers with an overview of the application of Ta in the treatment of IBDs.

更新日期：2022-12-23

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南