European Journal of Medicinal Chemistry (EJMC) has been around for a long time and has gained broad interest from the various individuals working in the field. However, there is no bibliometric analysis on the publications of EJMC to thoroughly assess the scientific output and current status systematically. Therefore, the study was conducted to analyze the various publications of EJMC from 1987 to 2022 to improve their quality. A total of 13,386 papers were retrieved, with the number of publications increasing yearly. Based on the multiple indicators of bibliometrics, the highest impact countries, institutions, authors and representative literature were identified, and visualization networks were constructed using VOSviewer. Keyword co-occurrence analysis reveals a gradual shift from phenotypic drug discovery to target-based drug discovery in the EJMC theme change. Moreover, further discussion of the keyword clustering results is provided to support researchers in defining the scope of their research topics and planning their research directions. At this stage, there is a greater focus on developing antitumor and oxidative stress-related drugs than on the earlier anti-infective activities. In future studies, the main research directions are tumor multidrug resistance, oxidative stress, and dual inhibitors.

欧洲药物化学杂志(EJMC) 已经存在了很长时间，并引起了在该领域工作的各种个人的广泛兴趣。然而，没有对 EJMC 出版物进行文献计量分析，以系统地全面评估其科学产出和现状。因此，本研究旨在分析 1987 年至 2022 年 EJMC 的各种出版物，以提高其质量。共检索到论文13386篇，发表篇数逐年递增。基于文献计量学的多项指标，确定影响最大的国家、机构、作者和代表性文献，并使用VOSviewer构建可视化网络。关键字共现分析揭示了在 EJMC 主题变化中从表型药物发现逐渐转变为基于目标的药物发现。而且，提供对关键词聚类结果的进一步讨论，以支持研究人员定义他们的研究主题范围和规划他们的研究方向。在这个阶段，与早期的抗感染活性相比，更侧重于开发抗肿瘤和氧化应激相关药物。在未来的研究中，主要研究方向为肿瘤多药耐药、氧化应激和双重抑制剂。