衰老对2型糖尿病大鼠Roux-en-Y胃旁路术后糖代谢改善的影响,Nutrition & Diabetes

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衰老对2型糖尿病大鼠Roux-en-Y胃旁路术后糖代谢改善的影响
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2022-12-23 , DOI: 10.1038/s41387-022-00229-9
Weijie Chen ₁ , Haixin Yin ₁ , Jianchun Xiao ₁ , Wei Liu ₁ , Qiang Qu ₁ , Fengying Gong ₂ , Xiaodong He ₁

Affiliation

背景

本研究旨在探讨衰老对 2 型糖尿病 (T2DM) 大鼠模型 Roux-en-Y 胃旁路手术 (RYGB) 后糖代谢改善的影响。

方法

20 只 Goto-Kakizaki 大鼠随机分为 RYGB-A 组和假 RYGB (SR-A) 组，10 只成年 Goto-Kakizaki 大鼠也接受 RYGB 程序 (RYGB-Y)。测量葡萄糖代谢、静息能量消耗 (REE)、胰高血糖素样肽-1 (GLP-1) 和总胆汁酸水平。

结果

RYGB可显着改善老年糖尿病大鼠糖代谢。RYGB-A组空腹血糖由术前的15.8±1.1 mmol/l下降至术后16周的12.3±1.5 mmol/l（ P < 0.01），AUC OGTT值由2603.9±155.4 （ mmol _）下降/l) min 至 2299.9 ± 252.8 (mmol/l) min ( P = 0.08)。RYGB-A组空腹血糖下降幅度小于RYGB-Y组（20.5%±6.5% vs. 40.6%±10.6%，P < 0.01），AUC OGTT下降幅度也小于RYGB - _Y 组值（11.6% ± 14.8% 对 38.5% ± 8.3%，P < 0.01)。此外，术后第16周，RYGB-A组REE增幅低于RYGB-Y组（15.3%±11.1% vs. 29.1%±12.1%，P=0.04 ）。RYGB-A组胆汁酸升高幅度小于RYGB-Y组（80.2±59.3% vs.212.3±139.0%，P < 0.01）。RYGB-A组的GLP-1水平低于RYGB-Y组（12.8±3.9pmol/L vs. 18.7±5.6pmol/L，P=0.02 ）。RYGB-A组与RYGB-Y组三碘甲腺原氨酸水平无显着差异。

结论

RYGB 可以诱导老年糖尿病大鼠的葡萄糖代谢改善，并且衰老可能会减弱 RYGB 的作用。

"点击查看英文标题和摘要"

The effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass in type 2 diabetes rats

Background

This study aimed to investigate the effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass (RYGB) in rat models with type 2 diabetes mellitus (T2DM).

Methods

Twenty aged Goto-Kakizaki rats were randomly assigned into RYGB-A group and sham RYGB (SR-A) group, and 10 adult Goto-Kakizaki rats also accept RYGB procedures (RYGB-Y). Glucose metabolism, resting energy expenditure (REE), glucagon-like peptide-1 (GLP-1) and total bile acid level were measured.

Results

RYGB could significantly improve glucose metabolism in aged diabetic rats. The fasting blood glucose level in the RYGB-A group decreased from 15.8 ± 1.1 mmol/l before surgery to 12.3 ± 1.5 mmol/l 16 weeks after surgery (P < 0.01), and the AUC_OGTT value decreased from 2603.9 ± 155.4 (mmol/l) min to 2299.9 ± 252.8 (mmol/l) min (P = 0.08). The decrease range of fasting blood glucose in the RYGB-A group was less than that in the RYGB-Y group (20.5% ± 6.5% vs. 40.6% ± 10.6%, P < 0.01), so is the decrease range of AUC_OGTT value (11.6% ± 14.8% vs. 38.5% ± 8.3%, P < 0.01). Moreover, at the 16th postoperative week, the increase range of REE of the RYGB-A group was lower than that of the RYGB-Y group (15.3% ± 11.1% vs. 29.1% ± 12.1%, P = 0.04). The increased range of bile acid of the RYGB-A group was less than that of the RYGB-Y group (80.2 ± 59.3 % vs.212.3 ± 139.0 %, P < 0.01). The GLP-1 level of the RYGB-A group was less than that of the RYGB-Y group (12.8 ± 3.9 pmol/L vs. 18.7 ± 5.6 pmol/L, P = 0.02). There was no significant difference between the RYGB-A group and the RYGB-Y group in the level of the triiodothyronine level.