Mn(III)-Mediated Radical Addition/Cyclization of Isocyanides with Aryl Boronic Acids/Diarylphosphine Oxides: Access to 11-Functionalized Dibenzodiazepines,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mn(III)-Mediated Radical Addition/Cyclization of Isocyanides with Aryl Boronic Acids/Diarylphosphine Oxides: Access to 11-Functionalized Dibenzodiazepines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-12-22 , DOI: 10.1021/acs.joc.2c02059
Xuan Liu ₁ , Sitian Yuan ₁ , Yi Liu ₁ , Mengjia Ni ₁ , Jianbo Xu ₁ , Shuanggen Gui ₁ , Yi-Yuan Peng ₁ , Qiuping Ding ₁

Affiliation

A Mn(III)-mediated radical addition/cyclization reaction of isocyanides with aryl boronic acids/diarylphosphine oxides has been developed. A series of 11-arylated/-phosphorylated dibenzodiazepines were efficiently constructed in moderate to excellent yields under mild reaction conditions via imidoyl radical process. The present protocol offers novel access to functionalized seven-membered N-heterocycles.

中文翻译：

Mn(III)-介导的异氰化物与芳基硼酸/二芳基氧化膦的自由基加成/环化：获得 11-官能化二苯并二氮杂卓

已经开发了 Mn(III) 介导的异氰化物与芳基硼酸/二芳基氧化膦的自由基加成/环化反应。一系列 11-芳基化/-磷酸化二苯二氮卓类化合物在温和的反应条件下通过亚氨基自由基过程以中等到优异的收率有效构建。本协议提供了对功能化七元N-杂环的新访问。

更新日期：2022-12-22

点击分享查看原文

点击收藏

阅读更多本刊新发论文