The surface enhanced Raman scattering (SERS) reporters are rather limited, and the Raman peaks still overlap in varying degrees, making SERS multiplex coding a critical bottleneck in the exploration of SERS nanotechnology. Herein, we design a general strategy to expand the SERS probe scope to 26 probes of six types, which can be further expanded within a limited range, with stable performance and structure. By constructing (Au-aggregate)@Ag@silica and (Au-aggregate)@silica nanocomposites, we develop optimal enhancement strategies for each Raman molecules. Mixed signal-ligand SERS probes improve the complexity of Raman spectra and expand the coding capacity. By integrating the strategies, SERS inks are produced and applied in anti-counterfeiting. With these improvements, this work breaks the constrains of probe selection, bringing SERS one step closer to the sensor or anti-counterfeiting application.

表面增强拉曼散射（SERS）报告基因相当有限，拉曼峰仍存在不同程度的重叠，使得SERS多重编码成为SERS纳米技术探索的关键瓶颈。在此，我们设计了一个总体策略，将 SERS 探针范围扩展到 6 种类型的 26 个探针，这些探针可以在有限的范围内进一步扩展，具有稳定的性能和结构。通过构建 (Au-aggregate)@Ag@silica 和 (Au-aggregate)@silica 纳米复合材料，我们为每个拉曼分子开发了最佳增强策略。混合信号-配体 SERS 探针提高了拉曼光谱的复杂性并扩展了编码容量。通过整合策略，生产SERS墨水并应用于防伪。通过这些改进，这项工作打破了探针选择的限制，