Retinoblastoma (RB), the most common malignant retinal tumor among children under 3 years old, is lethal if left untreated. Early diagnosis, together with timely and effective treatment, is important to improve retinoblastoma-related outcomes. Circular RNAs (circRNAs), a new class of non-coding RNAs with the capacity to regulate cellular activities, have great potential in retinoblastoma diagnosis and treatment. Recent studies have identified circular RNAs that regulate multiple cellular processes involved in retinoblastoma, including cell viability, proliferation, apoptosis, autophagy, migration, and invasion. Six circular RNAs (circ-FAM158A, circ-DHDDS, circ-E2F3, circ-TRHDE, circ-E2F5, and circ-RNF20) promote disease progression and metastasis in retinoblastoma and function as oncogenic factors. Other circular RNAs, such as circ-TET1, circ-SHPRH, circ-MKLN1, and circ-CUL2, play tumor suppressive roles in retinoblastoma. At present, the studies on the regulatory mechanism of circular RNAs in retinoblastoma are not very clear. The purpose of this review is to summarize recent studies on the functional roles and molecular mechanisms of circular RNAs in retinoblastoma and highlight novel strategies for retinoblastoma diagnosis, prognosis, and treatment.

视网膜母细胞瘤 (RB) 是 3 岁以下儿童中最常见的恶性视网膜肿瘤，如果不及时治疗会致命。早期诊断以及及时有效的治疗对于改善视网膜母细胞瘤相关结果非常重要。环状 RNA (circRNA) 是一类具有调节细胞活动能力的新型非编码 RNA，在视网膜母细胞瘤的诊断和治疗中具有巨大潜力。最近的研究已经确定了调节视网膜母细胞瘤涉及的多个细胞过程的环状 RNA，包括细胞活力、增殖、细胞凋亡、自噬、迁移和侵袭。六种环状 RNA（circ-FAM158A、circ-DHDDS、circ-E2F3、circ-TRHDE、circ-E2F5 和 circ-RNF20）促进视网膜母细胞瘤的疾病进展和转移，并作为致癌因子发挥作用。其他环状 RNA，如 circ-TET1，circ-SHPRH、circ-MKLN1 和 circ-CUL2 在视网膜母细胞瘤中发挥肿瘤抑制作用。目前，环状RNAs在视网膜母细胞瘤中的调控机制研究还不是很清楚。本综述的目的是总结最近关于环状 RNA 在视网膜母细胞瘤中的功能作用和分子机制的研究，并强调视网膜母细胞瘤诊断、预后和治疗的新策略。