This study aimed to evaluate the protective effects of quercetin on the biochemical parameters, immunity, and growth performance in malathion-exposed common carp, Cyprinus carpio. The methods six experimental groups, including the control group, fish exposed to concentrations of 1.04 and 2.08 mg/l malathion, fish supplemented with quercetin (200 mg/kg diet), and fish treated with quercetin + malathion for 21 days, were considered for the experiment. After the feeding period, in results the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) were significantly decreased in the hepatocyte, while malondialdehyde (MDA) content increased in response to malathion. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and glucose, cortisol, and urea levels significantly increased after exposure to malathion. Exposure of fish to malathion-induced decreases in protease, lysozyme, and alternative complement (ACH50) activities and total immunoglobulin (total Ig) in the mucosa. Changes in other parameters were different depending on malathion concentrations. The supplementation of fish with quercetin had no ameliorating effect on the malathion-related alternations of mucosal lysozyme and protease activities. However, quercetin ameliorated the depressing effects of malathion on biochemical and immunological parameters. Changes in the growth performance and hematological parameters indicated the toxic effect of malathion. In conclusion, quercetin could efficiently reduce the toxic effects of malathion on the biochemical, immune, and hematological parameters of the common carp.