<br>超快魔角旋转固态核磁共振波谱：方法和应用的进展,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

超快魔角旋转固态核磁共振波谱：方法和应用的进展
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-12-21 , DOI: 10.1021/acs.chemrev.2c00197
Yusuke Nishiyama _{1,

2} , Guangjin Hou ₃ , Vipin Agarwal ₄ , Yongchao Su ₅ , Ayyalusamy Ramamoorthy ₆

Affiliation

固态核磁共振波谱是研究各种化学、生物、材料和制药系统的原子分辨率结构和动力学的最常用技术之一，涵盖多种形式，包括晶体、液晶、纤维和无定形状态。尽管固态核磁共振波谱具有独特的优势，但其较差的光谱分辨率和灵敏度严重限制了该技术的应用范围。幸运的是，探针技术的最新发展，可以快速机械旋转样品（100 kHz 及以上），以获得具有更高分辨率和灵敏度的“类溶液”固体 NMR 谱，为新型 NMR 技术及其应用的开发开辟了许多途径研究大量固体，包括球状和膜相关蛋白、淀粉样纤维等自组装蛋白聚集体、RNA、病毒组装体、多态药物、金属有机框架、骨材料和无机材料。在超快 MAS 不断发展的同时，微小的样品数量和射频要求、更短的循环延迟（可实现快速数据采集）、采用质子检测的可行性、质子光谱分辨率和偏振传输效率的增强以及每单位样品的高灵敏度文献报道的研究证明了超快 MAS 技术的一些显着优势。尽管极低的样品量和极高的射频功率可能会限制某些系统，但这些优势刺激了对日益复杂的生物和材料系统的固态核磁共振研究。随着超快 MAS NMR 技术越来越多地应用于多学科研究领域，人们同时追求仪器、探针和先进方法的进一步开发，以克服广泛应用的限制和挑战。这篇综述文章的重点是及时全面地报道超快 MAS 技术的仪器、理论、技术、应用、局限性和未来范围的主要发展。

"点击查看英文标题和摘要"

Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications

Solid-state NMR spectroscopy is one of the most commonly used techniques to study the atomic-resolution structure and dynamics of various chemical, biological, material, and pharmaceutical systems spanning multiple forms, including crystalline, liquid crystalline, fibrous, and amorphous states. Despite the unique advantages of solid-state NMR spectroscopy, its poor spectral resolution and sensitivity have severely limited the scope of this technique. Fortunately, the recent developments in probe technology that mechanically rotate the sample fast (100 kHz and above) to obtain “solution-like” NMR spectra of solids with higher resolution and sensitivity have opened numerous avenues for the development of novel NMR techniques and their applications to study a plethora of solids including globular and membrane-associated proteins, self-assembled protein aggregates such as amyloid fibers, RNA, viral assemblies, polymorphic pharmaceuticals, metal–organic framework, bone materials, and inorganic materials. While the ultrafast-MAS continues to be developed, the minute sample quantity and radio frequency requirements, shorter recycle delays enabling fast data acquisition, the feasibility of employing proton detection, enhancement in proton spectral resolution and polarization transfer efficiency, and high sensitivity per unit sample are some of the remarkable benefits of the ultrafast-MAS technology as demonstrated by the reported studies in the literature. Although the very low sample volume and very high RF power could be limitations for some of the systems, the advantages have spurred solid-state NMR investigation into increasingly complex biological and material systems. As ultrafast-MAS NMR techniques are increasingly used in multidisciplinary research areas, further development of instrumentation, probes, and advanced methods are pursued in parallel to overcome the limitations and challenges for widespread applications. This review article is focused on providing timely comprehensive coverage of the major developments on instrumentation, theory, techniques, applications, limitations, and future scope of ultrafast-MAS technology.

更新日期：2022-12-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南