Relationships of orexigenic and anorexigenic hormones with body fat distribution in patients with obstructive sleep apnea syndrome,European Archives of Oto-Rhino-Laryngology

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Relationships of orexigenic and anorexigenic hormones with body fat distribution in patients with obstructive sleep apnea syndrome
European Archives of Oto-Rhino-Laryngology ( IF 1.9 ) Pub Date : 2022-12-22 , DOI: 10.1007/s00405-022-07799-5
Arzu Or Koca ₁ , Ayşe İriz ₂ , Burak Hazır ₂ , Rabia Şemsi ₃ , Nirgül Bilger ₄ , Asiye Uğraş Dikmen ₅ , Aylin Sepici Dinçel ₃ , İlhan Yetkin ₆

Affiliation

Purpose

We aimed to examine the relationships of disease activity and risk factors with serum levels of orexigenic and anorexigenic hormones in patients with obstructive sleep apnea syndrome (OSAS).

Methods

Fasting blood samples were taken for hormonal analysis of all participants, abdominal/neck bioimpedance measurements were recorded, and polysomnography (PSG) analyses were performed. According to the apnea–hypopnea index (AHI), 34 patients with newly diagnosed OSAS and 34 participants without OSAS were compared.

Results

The median body mass index (BMI) measured in the OSAS group was 30.39 kg/m² and AHI was 18.95 and these values were 25.40 kg/m² and 1.55 in the control group. There was a higher level of visceral adiposity and neuropeptide Y (NPY) in the moderate-to-severe OSAS group compared to the mild OSAS and control groups, and in the mild OSAS group compared to the control group (p = 0.001, p < 0.001). A positive correlation between the level of NPY and AHI and BMI (p < 0.001, p = 0.011), and a negative correlation between NPY levels and oxygen saturation (p = 0.001) was found. Oxygen saturation and desaturation rates were correlated with body fat percentage, body fat mass, abdominal adiposity, visceral adiposity, resting metabolic rate, and NPY levels.

Conclusions

The visceral adiposity ratio and increase in NPY levels are important parameters that increase the severity of OSAS. Considering the negative effects of NPY on vascular endothelium, measurement of basal NPY level before PSG in patients with OSAS is considered a parameter related to disease severity.

中文翻译：

阻塞性睡眠呼吸暂停综合征患者食欲和厌食激素与体脂分布的关系

目的

我们的目的是检查阻塞性睡眠呼吸暂停综合征 (OSAS) 患者的疾病活动和危险因素与血清中促食欲激素和促厌食激素水平之间的关系。

方法

采集空腹血样对所有参与者进行激素分析，记录腹部/颈部生物阻抗测量值，并进行多导睡眠图 (PSG) 分析。根据呼吸暂停低通气指数 (AHI)，比较了 34 名新诊断的 OSAS 患者和 34 名没有 OSAS 的参与者。

结果

OSAS 组测得的中位体重指数 (BMI) 为 30.39 kg/m ²，AHI 为 18.95，而对照组的这些值为 25.40 kg/m ^{2和 1.55。}与轻度 OSAS 和对照组相比，中度至重度 OSAS 组的内脏肥胖和神经肽 Y (NPY) 水平更高，轻度 OSAS 组与对照组相比（p = 0.001 ，p < 0.001）。NPY 水平与 AHI 和 BMI 呈正相关 ( p < 0.001, p = 0.011)，NPY 水平与氧饱和度呈负相关 ( p = 0.001) 被发现。氧饱和度和去饱和率与体脂百分比、体脂量、腹部肥胖、内脏肥胖、静息代谢率和 NPY 水平相关。