Sequential Methods for Di- and Tetrahydro-Pyranone Synthesis Enable Concise Access to Tuscolid δ-Lactone,Chemistry - An Asian Journal

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Sequential Methods for Di- and Tetrahydro-Pyranone Synthesis Enable Concise Access to Tuscolid δ-Lactone
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2022-12-21 , DOI: 10.1002/asia.202201193
Xin Gao ₁ , Dirk Menche ₁

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Two novel sequential approaches for elaborate hydro pyranone synthesis were developed that relied either on an aldol-lactonization sequence of an unprotected aldehyde with a chiral enolate or a challenging dienolate ketone addition with subsequent cyclization. These procedures enable concise and short preparations of the authentic subunit of the polyketide macrolide tuscolid.

中文翻译：

二氢吡喃酮和四氢吡喃酮合成的序贯方法使获得 Tuscolid δ-内酯成为可能

开发了两种用于精细氢吡喃酮合成的新型顺序方法，它们依赖于未保护醛与手性烯醇化物的羟醛-内酯化序列，或具有挑战性的二烯醇酮加成和随后的环化。这些程序使聚酮化合物大环内酯 tuscolid 的真实亚基的简明和简短的准备成为可能。

更新日期：2022-12-21

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