Abstract

Poly(glycerol sebacate) (PGS) and its derivatives have been developed and used for various biomedical applications over the past two decades. Several publications have reviewed the development of PGS from different perspectives, typically focusing on the biofabrication techniques and intended biomedical applications of PGS. However, a comprehensive review of the progress in the research on PGS and its derivatives over the past two decades, in terms of material design, synthesis, and properties have not been conducted. Herein, we review the design and preparation of PGS using different synthesis processes, ranging from the traditional heat curing method to various novel synthesis approaches, before systematically exploring the development of novel PGS derivatives prepared by functional groups modification or (and) hybridizing with other substances. Moreover, a statistical analysis of related publications is presented to quantify the progress in the research on PGS and its derivatives from different perspectives and identify any trends. We expect that this review and the design principles of PGS-based materials summarized herein will inform and promote the further development and optimization of PGS and its derivatives for biomedical applications.

摘要

在过去的二十年中，聚癸二酸甘油酯（PGS）及其衍生物已被开发并用于各种生物医学应用。一些出版物从不同角度回顾了 PGS 的发展，通常侧重于 PGS 的生物制造技术和预期的生物医学应用。然而，尚未对过去二十年PGS及其衍生物在材料设计、合成和性能方面的研究进展进行全面回顾。在此，我们回顾了从传统的热固化方法到各种新型合成方法的不同合成工艺的设计和制备PGS，然后系统地探索了通过官能团修饰或（和）与其他物质杂化制备的新型PGS衍生物的开发。此外，还对相关出版物进行了统计分析，从不同角度量化了 PGS 及其衍生物的研究进展并确定了趋势。我们期望本文总结的本综述和基于 PGS 的材料的设计原理将为生物医学应用的 PGS 及其衍生物的进一步开发和优化提供信息和促进。