Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines,Nature Reviews Immunology

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Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2022-12-20 , DOI: 10.1038/s41577-022-00825-x
Yi Ju _{1,

2} , Juan Manuel Carreño _{3,

4} , Viviana Simon _{3,

4,

5,

6,

7} , Kenneth Dawson ₈ , Florian Krammer _{3,

4,

5} , Stephen J Kent _{1,

9}

Affiliation

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
School of Science and School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Centre for BioNano Interactions, School of Chemistry, University College Dublin, Dublin, Ireland.
Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.

中文翻译：

SARS-CoV-2 mRNA 疫苗诱导的抗 PEG 抗体的影响

针对 COVID-19 的成功 mRNA 疫苗含有聚乙二醇 (PEG) 来稳定脂质纳米颗粒。最近的数据表明，mRNA 疫苗接种可以诱导或增强 PEG 特异性抗体。需要进一步研究 PEG 特异性抗体、疫苗反应原性和其他含 PEG 药物的增强清除之间的潜在联系。

更新日期：2022-12-20

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