Beyond Warburg: LDHA activates RAC for tumour growth,Nature Metabolism

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Beyond Warburg: LDHA activates RAC for tumour growth
Nature Metabolism ( IF 18.9 ) Pub Date : 2022-12-19 , DOI: 10.1038/s42255-022-00709-3
Natsuski Osaka ₁ , Atsuo T Sasaki _{1,

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Affiliation

The physiological role of aerobic glycolysis (also known as the Warburg effect), which is observed in many tumours, is still not fully understood. The finding that lactate dehydrogenase A (LDHA) activates RAC1 in breast cancer sheds new light on this persistently enigmatic aspect of cancer metabolism.

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