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Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis
Organic Letters ( IF 4.9 ) Pub Date : 2022-12-19 , DOI: 10.1021/acs.orglett.2c03840
Liu Yang 1 , Yonggang Yan 1 , Ni Cao 1 , Jing Hao 1 , Gang Li 1 , Wei Zhang 1 , Rui Cao 1 , Chao Wang 1 , Jianliang Xiao 2 , Dong Xue 1
Organic Letters ( IF 4.9 ) Pub Date : 2022-12-19 , DOI: 10.1021/acs.orglett.2c03840
Liu Yang 1 , Yonggang Yan 1 , Ni Cao 1 , Jing Hao 1 , Gang Li 1 , Wei Zhang 1 , Rui Cao 1 , Chao Wang 1 , Jianliang Xiao 2 , Dong Xue 1
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A highly efficient hydroxylation of (hetero)aryl halides using water as a hydroxyl source via Ni catalysis promoted by PhSiH3 under thermal catalysis is reported. This methodology provides a general procedure to obtain diverse multifunctional pharmaceutically phenols and polyphenols, some of which are proven challenging to be synthesized using literature methods. Mechanism studies demonstrated that the addition of PhSiH3 led to the generation of active Ni(I) species, which catalyze the hydroxylation via a Ni(I)–Ni(III) pathway.
中文翻译:
热催化下 Ni(I) 催化芳基卤化物与水的羟基化反应
报道了在热催化下,通过 PhSiH 3促进的 Ni 催化,使用水作为羟基源对(杂)芳基卤化物进行高效羟基化。该方法提供了获得多种多功能药用酚和多酚的一般程序,其中一些已被证明难以使用文献方法合成。机理研究表明,添加 PhSiH 3会导致活性 Ni(I) 物质的产生,其通过 Ni(I)–Ni(III) 途径催化羟基化。
更新日期:2022-12-19
中文翻译:
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热催化下 Ni(I) 催化芳基卤化物与水的羟基化反应
报道了在热催化下,通过 PhSiH 3促进的 Ni 催化,使用水作为羟基源对(杂)芳基卤化物进行高效羟基化。该方法提供了获得多种多功能药用酚和多酚的一般程序,其中一些已被证明难以使用文献方法合成。机理研究表明,添加 PhSiH 3会导致活性 Ni(I) 物质的产生,其通过 Ni(I)–Ni(III) 途径催化羟基化。