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Metabolism Difference Is Involved in Mesosulfuron-Methyl Selectivity between Aegilops tauschii and Triticum aestivum
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-12-19 , DOI: 10.1021/acs.jafc.2c05809
Haiyan Yu 1 , Xiaotong Guo 2 , Hailan Cui 1 , Jingchao Chen 1 , Xiangju Li 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-12-19 , DOI: 10.1021/acs.jafc.2c05809
Haiyan Yu 1 , Xiaotong Guo 2 , Hailan Cui 1 , Jingchao Chen 1 , Xiangju Li 1
Affiliation
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The acetolactate synthase (ALS) inhibitor mesosulfuron-methyl is currently the only selective herbicide to control Aegilops tauschii in wheat fields; however, the mechanism underlying this selectivity remains unclear. Results showed that the tolerance of Triticum aestivum to mesosulfuron-methyl was much higher than that of A. tauschii. Mesosulfuron-methyl inhibited the in vitro ALS activity of A. tauschii and T. aestivum similarly, but the predicted structural interactions of ALS with mesosulfuron-methyl and induced expression of als were different in the two species. Compared with T. aestivum, A. tauschii was found to absorb more mesosulfuron-methyl and metabolize much less mesosulfuron-methyl. The cytochrome P450 monooxygenase (CYP450) inhibitor, malathion, greatly increased the sensitivity of T. aestivum to mesosulfuron-methyl, while its synergistic effect was smaller in A. tauschii. Finally, 19 P450 genes were selected as candidate genes related with metabolism-based mesosulfuron-methyl selectivity. Collectively, different sensitivities to mesosulfuron-methyl in the two species were likely to be attributed to metabolism variances.
中文翻译：
节磺隆与小麦之间的代谢差异涉及甲基磺隆选择性
The acetolactate synthase (ALS) inhibitor mesosulfuron-methyl is currently the only selective herbicide to control Aegilops tauschii in wheat fields; however, the mechanism underlying this selectivity remains unclear. Results showed that the tolerance of Triticum aestivum to mesosulfuron-methyl was much higher than that of A. tauschii. Mesosulfuron-methyl inhibited the in vitro ALS activity of A. tauschii and T. aestivum similarly, but the predicted structural interactions of ALS with mesosulfuron-methyl and induced expression of als were different in the two species. Compared with T. aestivum, A. tauschii发现吸收更多的甲基磺隆并代谢更少的甲基磺隆。细胞色素P450单加氧酶（CYP450）抑制剂马拉硫磷大大提高了普通小麦对甲基磺隆的敏感性，而在节节麦中的协同作用较小。最后，选择了 19 个 P450 基因作为与基于代谢的甲基磺隆选择性相关的候选基因。总的来说，这两个物种对甲基磺隆的不同敏感性可能归因于代谢差异。
更新日期：2022-12-19
中文翻译：
节磺隆与小麦之间的代谢差异涉及甲基磺隆选择性
The acetolactate synthase (ALS) inhibitor mesosulfuron-methyl is currently the only selective herbicide to control Aegilops tauschii in wheat fields; however, the mechanism underlying this selectivity remains unclear. Results showed that the tolerance of Triticum aestivum to mesosulfuron-methyl was much higher than that of A. tauschii. Mesosulfuron-methyl inhibited the in vitro ALS activity of A. tauschii and T. aestivum similarly, but the predicted structural interactions of ALS with mesosulfuron-methyl and induced expression of als were different in the two species. Compared with T. aestivum, A. tauschii发现吸收更多的甲基磺隆并代谢更少的甲基磺隆。细胞色素P450单加氧酶（CYP450）抑制剂马拉硫磷大大提高了普通小麦对甲基磺隆的敏感性，而在节节麦中的协同作用较小。最后，选择了 19 个 P450 基因作为与基于代谢的甲基磺隆选择性相关的候选基因。总的来说，这两个物种对甲基磺隆的不同敏感性可能归因于代谢差异。
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