Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field
Small ( IF 13.0 ) Pub Date : 2022-12-16 , DOI: 10.1002/smll.202205053 Yizhang Wu 1 , Xueru Song 2 , Xiaoyu Zhou 3 , Renjie Song 4 , Wenchao Tang 5 , Dingyi Yang 6 , Yong Wang 6 , Zhongyang Lv 7 , Wei Zhong 5 , Hong-Ling Cai 5 , Aimei Zhang 1 , Jia Wei 2, 8 , X S Wu 5, 9
Small ( IF 13.0 ) Pub Date : 2022-12-16 , DOI: 10.1002/smll.202205053 Yizhang Wu 1 , Xueru Song 2 , Xiaoyu Zhou 3 , Renjie Song 4 , Wenchao Tang 5 , Dingyi Yang 6 , Yong Wang 6 , Zhongyang Lv 7 , Wei Zhong 5 , Hong-Ling Cai 5 , Aimei Zhang 1 , Jia Wei 2, 8 , X S Wu 5, 9
Affiliation
|
Monolayer molybdenum disulfide (MoS2) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain. However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2, quenching of piezo-generated charges, and monotherapy. Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3C2 (TC), to self-assemble a multimodal nanoplatform, Ti3C2-Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation. TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2, but also maintains remarkable stability. Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron–hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding. Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2O2 in the tumor microenvironment under mechanical vibration. TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity. Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy. Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible. This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
中文翻译：
压电激活的原子薄二硫化钼/MXene 纳米酶，用于通过超声触发的肖特基电场进行综合高效的肿瘤治疗
单层二硫化钼 (MoS 2 ) 纳米酶具有压电极化作用，可在超声应变下产生活性氧以灭活肿瘤。然而，由于可堆叠的 MoS 2、压电产生电荷的淬灭和单一疗法，其治疗效果远非令人满意。在此，壳聚糖剥离的单层 MoS 2 (Ch-MS) 与原子薄的 MXene Ti 3 C 2 (TC)复合，以自组装多峰纳米平台 Ti 3 C 2 -壳聚糖-MoS 2 (TC@Ch -MS)，用于肿瘤灭活。TC@Ch-MS 不仅继承了单层 MoS2 的压电性, 但也保持了显着的稳定性。本征金属 MXene 与 MoS 2结合构建界面肖特基异质结，促进电子-空穴对的分离并赋予 TC@Ch-MS 增加灵敏度的磁共振成像响应。肖特基界面还导致过氧化物酶模拟物对 H 2 O 2具有优异的催化性能在机械振动下的肿瘤微环境中。TC@Ch-MS 在近红外线照射下具有比原始 TC 更高的光热转换效率，这归因于其增强的层间电导率。同时，TC@Ch-MS通过免疫疗法实现了对肿瘤细胞凋亡的优化效率。因此，TC@Ch-MS实现了集成诊断和多模式治疗的纳米平台，而对正常组织细胞的毒性可以忽略不计。这项工作可能为优化生物应用中的压电材料提供新的思路，并突出 MXene 中固有金属性的重要性。
更新日期：2022-12-16
中文翻译：
压电激活的原子薄二硫化钼/MXene 纳米酶，用于通过超声触发的肖特基电场进行综合高效的肿瘤治疗
单层二硫化钼 (MoS 2 ) 纳米酶具有压电极化作用，可在超声应变下产生活性氧以灭活肿瘤。然而，由于可堆叠的 MoS 2、压电产生电荷的淬灭和单一疗法，其治疗效果远非令人满意。在此，壳聚糖剥离的单层 MoS 2 (Ch-MS) 与原子薄的 MXene Ti 3 C 2 (TC)复合，以自组装多峰纳米平台 Ti 3 C 2 -壳聚糖-MoS 2 (TC@Ch -MS)，用于肿瘤灭活。TC@Ch-MS 不仅继承了单层 MoS2 的压电性, 但也保持了显着的稳定性。本征金属 MXene 与 MoS 2结合构建界面肖特基异质结，促进电子-空穴对的分离并赋予 TC@Ch-MS 增加灵敏度的磁共振成像响应。肖特基界面还导致过氧化物酶模拟物对 H 2 O 2具有优异的催化性能在机械振动下的肿瘤微环境中。TC@Ch-MS 在近红外线照射下具有比原始 TC 更高的光热转换效率，这归因于其增强的层间电导率。同时，TC@Ch-MS通过免疫疗法实现了对肿瘤细胞凋亡的优化效率。因此，TC@Ch-MS实现了集成诊断和多模式治疗的纳米平台，而对正常组织细胞的毒性可以忽略不计。这项工作可能为优化生物应用中的压电材料提供新的思路，并突出 MXene 中固有金属性的重要性。
京公网安备 11010802027423号