Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population,Cancer Medicine

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Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population
Cancer Medicine ( IF 2.9 ) Pub Date : 2022-12-16 , DOI: 10.1002/cam4.5541
Masashi Kanai ₁ , Takahisa Kawaguchi ₂ , Masahito Kotaka ₃ , Dai Manaka ₄ , Junichi Hasegawa ₅ , Akinori Takagane ₆ , Yoshinori Munemoto ₇ , Takeshi Kato ₈ , Tetsuya Eto ₉ , Tetsuo Touyama ₁₀ , Takanori Matsui ₁₁ , Katsunori Shinozaki ₁₂ , Shigemi Matsumoto ₁₃ , Tsunekazu Mizushima ₁₄ , Masaki Mori ₁₅ , Junichi Sakamoto _{16,

17} , Atsushi Ohtsu ₁₈ , Takayuki Yoshino ₁₈ , Shigetoyo Saji ₁₆ , Fumihiko Matsuda ₂

Affiliation

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan.
Department of Surgery, Gastrointestinal Center, Kyoto Katsura Hospital, Kyoto, Japan.
Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.
Department of Surgery, Hakodate Goryoukaku Hospital, Hakodate, Japan.
Department of Surgery, Fukui Ken Saiseikai Hospital, Fukui, Japan.
Department of Surgery, Kansai Rosai Hospital, Amagasaki, Japan.
Department of Gastroenterology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Department of Surgery, Nakagami Hospital, Okinawa, Japan.
Department of Gastroenterological Surgery, Aichi Cancer Center Aichi Hospital, Okazaki, Japan.
Division of Clinical Oncology, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Department of Real World Data Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Tokai University School of Medicine, Isehara, Japan.
Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo, Japan.
Tokai Central Hospital, Kakamigahara, Japan.
Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)-induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype-based FP dosing strategy.

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