Intracellular Glucose-Depriving Polymer Micelles for Antiglycolytic Cancer Treatment,Advanced Materials

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Intracellular Glucose-Depriving Polymer Micelles for Antiglycolytic Cancer Treatment
Advanced Materials ( IF 27.4 ) Pub Date : 2022-12-16 , DOI: 10.1002/adma.202207342
Jangwook Lee _{1,

2,

3} , Kwangmeyung Kim ₄ , Ick Chan Kwon _{5,

6} , Kuen Yong Lee ₁

Affiliation

A new anticancer strategy to exploit abnormal metabolism of cancer cells rather than to merely control the drug release or rearrange the tumor microenvironment is reported. An antiglycolytic amphiphilic polymer, designed considering the unique metabolism of cancer cells (Warburg effect) and aimed at the regulation of glucose metabolism, is synthesized through chemical conjugation between glycol chitosan (GC) and phenylboronic acid (PBA). GC-PBA derivatives form stable micellar structures under physiological conditions and respond to changes in glucose concentration. Once the micelles accumulate at the tumor site, intracellular glucose capture occurs, and the resultant energy deprivation through the inhibition of aerobic glycolysis remarkably suppresses tumor growth without significant side effects in vivo. This strategy highlights the need to develop safe and effective cancer treatment without the use of conventional anticancer drugs.

中文翻译：

用于抗糖酵解癌症治疗的细胞内葡萄糖剥夺聚合物胶束

报道了一种新的抗癌策略，利用癌细胞的异常代谢，而不是仅仅控制药物释放或重新排列肿瘤微环境。通过乙二醇壳聚糖 (GC) 和苯硼酸 (PBA) 之间的化学偶联，合成了一种抗糖酵解两亲聚合物，该聚合物考虑到癌细胞的独特代谢（Warburg 效应）并旨在调节葡萄糖代谢。GC-PBA 衍生物在生理条件下形成稳定的胶束结构，并对葡萄糖浓度的变化作出反应。一旦胶束在肿瘤部位积聚，就会发生细胞内葡萄糖捕获，通过抑制有氧糖酵解产生的能量剥夺显着抑制了肿瘤生长，而没有明显的体内副作用。

更新日期：2022-12-16

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