Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on a temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) is proposed, capable of eliminating deeply seated tumor cells while lowering risks of overtemperature (causes the death of healthy cells around the tumor). The THFOW is fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, and shows a remarkable soft tissue-affinity (low cytotoxicity, swelling stability, and soft tissue-like Young’s modulus). Moreover, the THFOW shows an excellent light propagation property with different wavenumbers (especially −0.32 dB cm⁻¹ with 915 nm laser light), and temperature-gated light propagation effect. The THFOW and relevant therapeutic strategy offer a promising application for intelligent photomedicine in deep issue.

光医学以其无毒、选择性好、创伤小等优点受到广泛关注。然而，由于光的穿透力有限且光媒体疗法难以监测，因此在深层组织中应用光医学治疗具有挑战性，因为它们可能会损害正常组织。在此，提出了一种基于温度自适应水凝胶纤维光波导 (THFOW) 的热调节介入光医学，能够消除深部肿瘤细胞，同时降低过热风险（导致肿瘤周围健康细胞死亡）。THFOW 采用一体化均质-动态-交联-纺丝法制造，具有显着的软组织亲和性（低细胞毒性、溶胀稳定性和类软组织杨氏模量）。而且，⁻¹ 915 nm 激光）和温度门控光传播效应。THFOW 和相关的治疗策略为深度问题的智能光医学提供了一个有前途的应用。