Facile Synthesis of Fully Substituted 1,2,4-Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal-Free Conditions,Asian Journal of Organic Chemistry

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Facile Synthesis of Fully Substituted 1,2,4-Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal-Free Conditions
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-12-15 , DOI: 10.1002/ajoc.202200674
Dahan Wang ₁ , Xiaoyuan Wan ₂ , Yazheng Zhou ₂ , Jinbing Liu ₃ , Jinhui Cai ₄ , Guo-Jun Deng ₂

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An efficient synthesis of densely 1,2,4-triazoles has been achieved by [3+2] cycloaddition of nitrileimides with amidine hydrochlorides under transition metal-free conditions. A series of aryl, heterocyclic and alkyl substituted 3-CF₃-1,2,4-triazoles were synthesized smoothly under the promotion of NaHCO₃ and yield up to 96%.

中文翻译：

在无过渡金属条件下通过腈亚胺与脒的 [3+2] 环加成反应轻松合成完全取代的 1,2,4-三唑

在无过渡金属条件下，通过腈酰亚胺与脒盐酸盐的 [3+2] 环加成反应，实现了稠密 1,2,4-三唑的有效合成。在NaHCO ₃的催化下，顺利合成了一系列芳基、杂环和烷基取代的3-CF ₃ -1,2,4-三唑，收率高达96%。

更新日期：2022-12-15

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