Metal-Doped Boron Quantum Dots for Versatile Detection of Lactate and Fluorescence Bioimaging,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metal-Doped Boron Quantum Dots for Versatile Detection of Lactate and Fluorescence Bioimaging
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-12-15 , DOI: 10.1021/acsami.2c17321
Meng Yang ₁ , Hui Jin ₁ , Rijun Gui ₁

Affiliation

To improve the stability and fluorescence (FL) of monoelemental boron nanomaterials, this work put forward a metal-coordination strategy to explore emerging metal-doped boron quantum dots, Co@BQDs. Through theoretical calculations, B–Co bonding as predicted can suppress the B–O reaction and protect the electronic structures of exfoliated two-dimensional (2D) boron from oxidation and decomposition upon exposure to oxygen. In experimental studies, Co²⁺ was added into a dispersion liquid of bulk boron and subjected to probe sonication to promote Co²⁺ adsorption on the surface of exfoliated 2D boron, followed by Co²⁺ coordination with exposed boron atoms. Solvothermal treatment of exfoliated 2D boron resulted in the generation of Co²⁺-doped 0D boron Co@BQDs. Experimental results confirm that Co@BQDs have higher colloidal and FL stability than BQDs as a reference. B–Co bonding formation to suppress the B–O reaction ensures the high stability of exfoliated boron structures. A dispersion liquid of Co@BQDs with stable and bright FL was used for visual FL imaging of solutions and solid substrates. Based on enzymatic and cascade oxidation-induced FL quenching of Co@BQDs, a novel FL bio-probe of lactate was explored. This bio-probe, with a broad detection range of 0.01–10 mM and a low detection limit of 3.1 μM, enables FL sensing of lactate in biosamples and shows high detection recoveries of 98.0–102.8%. Moreover, this bio-probe realized versatile FL imaging and visual detection of lactate in liquid/solid-phase systems. These results demonstrate great prospects of Co@BQDs as emerging and efficient imaging reagents for long-term tracking and bioimaging applications.

中文翻译：

金属掺杂硼量子点用于乳酸和荧光生物成像的多功能检测

为了提高单元素硼纳米材料的稳定性和荧光 (FL)，这项工作提出了一种金属配位策略来探索新兴的金属掺杂硼量子点 Co@BQDs。通过理论计算，预测的 B-Co 键合可以抑制 B-O 反应，并保护剥离的二维 (2D) 硼的电子结构在暴露于氧气时不被氧化和分解。在实验研究中，将Co ²⁺添加到块状硼的分散液中并进行探针超声处理以促进Co ²⁺吸附在剥离的二维硼表面，随后Co ²⁺与暴露的硼原子配位。剥离的二维硼的溶剂热处理导致 Co ^2+的产生-掺杂的 0D 硼 Co@BQDs。实验结果证实，Co@BQDs 比作为参考的 BQDs 具有更高的胶体和 FL 稳定性。抑制 B-O 反应的 B-Co 键形成确保了剥离硼结构的高稳定性。具有稳定和明亮 FL 的 Co@BQDs 分散液用于溶液和固体基底的视觉 FL 成像。基于 Co@BQDs 的酶促和级联氧化诱导的 FL 猝灭，探索了一种新型的乳酸 FL 生物探针。这种生物探针具有 0.01–10 mM 的宽检测范围和 3.1 μM 的低检测限，能够对生物样品中的乳酸进行 FL 检测，并显示出 98.0–102.8% 的高检测回收率。此外，该生物探针实现了液/固相系统中乳酸的多功能 FL 成像和视觉检测。

更新日期：2022-12-15

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南