基于 Ag[I] 离子/3,3',5,5'-四甲基联苯胺 (TMB) 系统的抗坏血酸的比色/光热双模式传感检测,RSC Advances

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基于 Ag[I] 离子/3,3',5,5'-四甲基联苯胺 (TMB) 系统的抗坏血酸的比色/光热双模式传感检测
RSC Advances ( IF 3.9 ) Pub Date : 2022-12-15 , DOI: 10.1039/d2ra06770f
Ya Di ₁ , Jiyao Zheng ₁ , Yunwang Zhao ₁ , Zikai Yang ₁ , Changshun Xie ₁ , Jiahan Yu ₁ , Yue Zheng ₁ , Liming Gao ₁

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^{在这项工作中，开发了一种基于 Ag +} /3,3',5,5'-四甲基联苯胺 (TMB) 系统的比色法和光热双模式传感测定抗坏血酸 (AA) 的新策略。在该传感系统中，Ag ⁺可以氧化 TMB，具有从无色到蓝色的明显颜色变化，在 652 nm 处具有强吸光度，并且在 808 nm 激光照射下由于氧化 TMB (oxTMB) 的形成而产生光热效应。当 AA 存在时，oxTMB 减少，伴随着从蓝色变为无色，吸收峰强度和光热效应降低。AA 浓度与 652 nm 处的吸光度强度值和 0.2–10 μM 范围内的温度值呈负线性相关（A = −0.03 C+ 0.343 ( R ² , 0.9887; LOD, 50 nM); Δ T = −0.57 C + 8.453（R ²，0.997；LOD，7.8 nM））。在此基础上，提出了一种无需复杂的纳米材料合成的双模检测AA的传感方法。光热效应和比色信号为 AA 提供了双模式检测策略，克服了任何单一模式的局限性。这种比色和光热双模式检测在临床药物中AA的检测以及便携式和高灵敏度传感器的构建方面具有巨大潜力。

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Colorimetric/photothermal dual-mode sensing detection of ascorbic acid based on a Ag[I] ion/3,3′,5,5′-tetramethylbenzidine (TMB) system

In this work, a novel strategy of colorimetric and photothermal dual-mode sensing determination of ascorbic acid (AA) based on a Ag⁺/3,3′,5,5′-tetramethylbenzidine (TMB) system was developed. In this sensing system, Ag⁺ could oxidize TMB with a distinct color change from colorless to blue color, strong absorbance at 652 nm and a photothermal effect under 808 nm laser irradiation due to the formation of oxidized TMB (oxTMB). When AA was present, oxTMB was reduced accompanied by a change from blue to colorless, and a decrease in absorption peak intensity and the photothermal effect. AA concentration showed a negative linear correlation with the value of both the absorbance intensity at 652 nm and temperature in the range of 0.2–10 μM (A = −0.03C + 0.343 (R², 0.9887; LOD, 50 nM); ΔT = −0.57C + 8.453 (R², 0.997; LOD, 7.8 nM)). Based on this, a sensing approach for detection of AA was proposed with dual-mode and without the complicated synthesis of nanomaterials. The photothermal effect and colorimetric signal provided a dual-mode detection strategy for AA, overcoming the limitations of any single mode. This colorimetric and photothermal dual-mode detection has great potential in the detection of AA in clinical pharmaceuticals and the construction of portable and highly sensitive sensors.

更新日期：2022-12-15

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