Laminarin ameliorates alcohol-induced liver damage and its molecular mechanism in mice,Journal of Food Biochemistry

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Laminarin ameliorates alcohol-induced liver damage and its molecular mechanism in mice
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2022-12-14 , DOI: 10.1111/jfbc.14500
Tianyi Guo ₁ , Lingfeng Zhu _{1,

2} , Yaping Zhou ₁ , Shuai Han ₁ , Yunyun Cao ₁ , Zuomin Hu ₁ , Yi Luo ₃ , Liyuan Bao ₄ , Xiuxiu Wu ₁ , Dandan Qin ₁ , Qinlu Lin ₁ , Feijun Luo ₁

Affiliation

Alcoholic liver disease (ALD) has become a health issue globally. Laminarin, a low molecular weight marine-derived β-glucan, has been identified with multiple biological activities. In this study, the ameliorative effect on ALD of laminarin isolated from brown algae was investigated. Phenotypic, pathological alterations and biochemical characteristics indicated that laminarin administration (100 mg/kg/day) significantly alleviated liver injury and improved liver function in the alcohol-induced mice. Gene chip results indicated that laminarin treatment caused 52 up-regulated and 13 down-regulated genes in the hepatic tissues of alcohol-induced damage mice, and most of these genes are associated with regulation of oxidative stress (such as CYP450/glutathione-dependent antioxidation), Wnt signaling pathway, retinol metabolism, and cAMP pathway based on GO and KEGG analysis. PPI network analysis indicated that the downstream target genes lied in the hub of the net. Our experiments also confirmed the changed expressions of some target genes. Taken together, these results suggest that laminarin can ameliorate alcohol-induced damage in mice and its molecular mechanism lies in modulating anti-oxidation pathway, WNT pathway, and cAMP pathway, which regulate the expressions of downstream target genes and alleviate alcohol-induced damage. Our study provides new clue to prevent alcohol-induced damage and will be benefit to develop functional foods.

中文翻译：

昆布多糖改善小鼠酒精性肝损伤及其分子机制

酒精性肝病 (ALD) 已成为全球性的健康问题。昆布多糖是一种低分子量海洋来源的 β-葡聚糖，已被证实具有多种生物活性。在这项研究中，研究了从褐藻中分离出来的昆布多糖对 ALD 的改善作用。表型、病理学改变和生化特征表明，昆布多糖给药（100 mg/kg/天）可显着减轻酒精诱导小鼠的肝损伤并改善肝功能。基因芯片结果表明，昆布多糖处理引起酒精损伤小鼠肝组织中52个上调基因和13个下调基因，其中大部分基因与氧化应激调节有关（如CYP450/谷胱甘肽依赖性抗氧化), Wnt信号通路, 视黄醇代谢, 和基于 GO 和 KEGG 分析的 cAMP 通路。PPI 网络分析表明下游目标基因位于网络的中心。我们的实验也证实了一些靶基因表达的改变。综上所述，这些结果表明昆布多糖可以改善小鼠酒精损伤，其分子机制在于调节抗氧化通路、WNT通路和cAMP通路，从而调节下游靶基因的表达，减轻酒精损伤。我们的研究为防止酒精引起的损害提供了新的线索，将有助于开发功能性食品。这些结果表明昆布多糖可以改善小鼠酒精损伤，其分子机制在于调节抗氧化通路、WNT通路和cAMP通路，从而调节下游靶基因的表达，减轻酒精损伤。我们的研究为防止酒精引起的损害提供了新的线索，将有助于开发功能性食品。这些结果表明昆布多糖可以改善小鼠酒精损伤，其分子机制在于调节抗氧化通路、WNT通路和cAMP通路，从而调节下游靶基因的表达，减轻酒精损伤。我们的研究为防止酒精引起的损害提供了新的线索，将有助于开发功能性食品。

更新日期：2022-12-14

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